نتایج جستجو برای: antimetastatic

تعداد نتایج: 993  

Journal: :Life 2023

Lung cancer is the leading cause of mortality worldwide, and malignant melanomas are highly lethal owing to their elevated metastatic potential. Despite improvements in therapeutic approaches, treatments not completely effective. Thus, new drug candidates continuously sought. We synthesized mono- di-methoxylated cinnamic acid esters investigated antitumor A cell viability assay was performed id...

Journal: :Cancer research 2002
Xiaojun Huang Michael K Wong Huiming Yi Simon Watkins A Douglas Laird Stanley F Wolf Elieser Gorelik

The therapeutic efficacy of combined antiangiogenic and immune therapy was tested against weakly immunogenic and highly metastatic 4T1 breast tumor using SU6668, an angiogenesis inhibitor and recombinant murine (rm) B7.2-IgG fusion protein, an immunostimulator. SU6668 inhibits the tyrosine kinase activity of three angiogenic receptors VEGFR2 (Flk-1/KDR), PDGFRbeta, and FGFR1, which play a cruci...

Journal: :Pharmacological research 2009
Angelo A Izzo Michael Camilleri

Emerging evidence suggests that cannabinoids may exert beneficial effects in intestinal inflammation and cancer. Adaptive changes of the endocannabinoid system have been observed in intestinal biopsies from patients with inflammatory bowel disease and colon cancer. Studies on epithelial cells have shown that cannabinoids exert antiproliferative, antimetastatic and apoptotic effects as well as r...

Journal: :Acta poloniae pharmaceutica 2013
Ayesha Sethi Muhammad Sher Muhammad Rouf Akram Sabiha Karim Sonia Khiljee Ashif Sajjad Syed Nisar Hussain Shah Ghulam Murtaza

Albumin is one of the most extensively studied endogenous proteins which are used in the fabrication of drug delivery and diagnostic technologies during last 10 years. This review provides a summary of products involving the use of albumin as a drug delivery tool for getting better the pharmacokinetics of a drug by developing the targetted drug delivery systems and diagnosing the pathologies. U...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2013
Prasun Guha Engin Kaptan Gargi Bandyopadhyaya Sabina Kaczanowska Eduardo Davila Keyata Thompson Stuart S Martin Dhananjaya V Kalvakolanu Gerardo R Vasta Hafiz Ahmed

Cancer metastasis and immune suppression are critical issues in cancer therapy. Here, we show that a β-galactoside-binding lectin [galectin-3 (gal3)] that recognizes the Thomsen-Friedenreich disaccharide (TFD, Galβ1,3GalNAc) present on the surface of most cancer cells is involved in promoting angiogenesis, tumor-endothelial cell adhesion, and metastasis of prostate cancer cells, as well as evad...

Journal: :Cancer research 2011
Hong Xin Andreas Herrmann Karen Reckamp Wang Zhang Sumanta Pal Michael Hedvat Chunyan Zhang Wei Liang Anna Scuto Shaobu Weng Deborah Morosini Zhu A Cao Michael Zinda Robert Figlin Dennis Huszar Richard Jove Hua Yu

STAT3 has important functions in both tumor cells and the tumor microenvironment to facilitate cancer progression. The STAT regulatory kinase Janus-activated kinase (JAK) has been strongly implicated in promoting oncogenesis of various solid tumors, including the use of JAK kinase inhibitors such as AZD1480. However, direct evidence that JAK drives STAT3 function and cancer pathogenesis at the ...

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