BACKGROUND Pterygium is a proliferative disease with hyperplastic growth of corneoconjunctival fibro vascular tissue onto the cornea. Surgical therapy can be used to successfully manage pterygia; however, recurrence remains a problem. To reduce recurrence, surgical management may include autoconjunctival grafting, lamellar keratoplasty, amniotic membrane transplantation, and intraoperative anti...

Drug-induced DNA hypermethylation was observed to constitute one component of the response of human tumor cells to toxic concentrations of commonly used cancer chemotherapy agents. In both human lung adenocarcinoma cells (HTB-54) and human rhabdomyosarcoma cells (CCl-136), pulse exposures to the topoisomerase II inhibitors etoposide and nalidixic acid; to the antibiotic doxorubicin; to the micr...

The acute toxicity of 3-fluorotyrosine and of 3-fluorophenylalanine for animals was reported several years ago (2) and recently it was found that 2and 4-fluorophenylalanines likewise are toxic when administered to albino rats (3). 3-Fluorotyrosine and 3-fluorophenylalanine are very efficient in acting as antimetabolites for tyrosine and phenylalanine, respectively (4), while 4-fluorophenylalani...

OBJECTIVES Although Pseudomonas aeruginosa from cystic fibrosis patients are well known for their antibiotic resistance, isolates that are highly susceptible to multiple drug classes have also been encountered. In this study, hypersusceptible P. aeruginosa isolates were analysed for changes in intrinsic resistance mechanisms to explain the observed phenotype. METHODS P. aeruginosa strains PA3...

I N A PREVIOUS paper, the morphology of the lymphoid system of the rabbit during the development of transplantation immunity was described.1 The outstanding feature of the reaction was the proliferation of primitive cells ( hemocytoblasts ), which, although they first appeared in the lymph node contiguous to the graft, were eventually seen throughout the entire lymphatic apparatus of the animal...