نتایج جستجو برای: antimalarial drugs

تعداد نتایج: 228691  

2015
Jaline Gerardin Philip Eckhoff Edward A Wenger

BACKGROUND Antimalarial drugs are a powerful tool for malaria control and elimination. Artemisinin-based combination therapies (ACTs) can reduce transmission when widely distributed in a campaign setting. Modelling mass antimalarial campaigns can elucidate how to most effectively deploy drug-based interventions and quantitatively compare the effects of cure, prophylaxis, and transmission-blocki...

2015
Bryan T. Mott Richard T. Eastman Rajarshi Guha Katy S. Sherlach Amila Siriwardana Paul Shinn Crystal McKnight Sam Michael Norinne Lacerda-Queiroz Paresma R. Patel Pwint Khine Hongmao Sun Monica Kasbekar Nima Aghdam Shaun D. Fontaine Dongbo Liu Tim Mierzwa Lesley A. Mathews-Griner Marc Ferrer Adam R. Renslo James Inglese Jing Yuan Paul D. Roepe Xin-zhuan Su Craig J. Thomas

Drug resistance in Plasmodium parasites is a constant threat. Novel therapeutics, especially new drug combinations, must be identified at a faster rate. In response to the urgent need for new antimalarial drug combinations we screened a large collection of approved and investigational drugs, tested 13,910 drug pairs, and identified many promising antimalarial drug combinations. The activity of ...

Journal: :The American Journal of Tropical Medicine and Hygiene 2017

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