BACKGROUND & OBJECTIVES Under the national antimalaria programme DDT was introduced in early 1950s for vector control and later hexachloro cyclohexane (HCH) followed by malathion and recently synthetic pyrethroids in 1990s to manage the insecticide resistance in Anopheles culicifacies. Subsequent replacement led to development of multiple resistances in An. culicifacies in Surat district in Guj...

While the malaria outlook in recent years has either remained the same or shown improvement in some parts of South America, the number of reported malaria cases in certain parts of Middle America has continued to increase (I). The eighteenth report of the WHO Expert Committee on Malaria, published in 1980 (2), lists twelve constraints impeding the progress of antimalaria activities. These inclu...

Glioma stem cells (GSCs) have been proven to play key roles in tumorigenesis, metastasis and recurrence. Although dihydroartemisinin (DHA), a derivative of the antimalaria drug artemisinin, has been shown to have anti-cancer activity, it is still unclear whether DHA affects GSCs. This study investigated the effects of DHA on the growth and apoptosis of GSCs, as well as the possible molecular me...

In an area of India where the main rural malaria vector, Anopheles culicifacies Giles, has developed triple resistance to DDT, HCH, and malathion sprayed indoors in antimalaria program, bifenthrin (10% wettable powder) was evaluated in a randomized house-scale trial between July 1999 and March 2000. Entomological impact of four serial doses of bifenthrin (25, 50, 100, and 200 mg/m2) sprayed in ...

ownload sesquiterpene lactone dihydroartemisinin (DHA), a semisynthetic derivative of the herbal antimalaria rtemisinin, is cytotoxic to human tumor cells. Treatment of Jurkat T-lymphoma cells with DHA ina breakdown of the mitochondrial transmembrane potential, release of cytochrome c, activation of es, and DNA fragmentation indicative of apoptosis induction. Although the absence of FADD or e-8...

BACKGROUND An understanding of the febrile illness experience of Nigerian nomadic Fulani is necessary for developing an appropriate strategy for extending malaria intervention services to them. An exploratory study of their malaria illness experience was carried out in Northern Nigeria preparatory to promoting malaria intervention among them. METHODS Ethnographic tools including interviews, g...

The sesquiterpene lactone dihydroartemisinin (DHA), a semisynthetic derivative of the herbal antimalaria drug artemisinin, is cytotoxic to human tumor cells. Treatment of Jurkat T-lymphoma cells with DHA induced a breakdown of the mitochondrial transmembrane potential, release of cytochrome c, activation of caspases, and DNA fragmentation indicative of apoptosis induction. Although the absence ...

Background: In nonmalaria regions, iron/folic acid supplementation during pregnancy protects newborns against preterm delivery and early neonatal death. Other studies from malaria-endemic areas have reported an adverse effect of iron supplements on malaria prevalence in pregnant women. Objective: We examined the association between iron/folic acid supplements and prenatal antimalaria prophylaxi...

BACKGROUND & OBJECTIVES Malaria is a serious problem in the countries of the developing world. As the malaria parasite has become resistant to most of the antimalaria drugs available currently, there is a need to search for newer drugs. This study reports the pharmaceutical quality and in vivo antimalarial activities of a polyherbal formulation (SAABMAL ® ) used as malarial remedy in Nigeria. ...

Background: β-Hematin (Hemozoin) was synthised inside human erythrocyte by malaria parasite. The parasite avoids the toxic effects by polymerizing heme molecules into insoluble crystalline β-Hematin. C. botrys and A. annua used for the treatment of diseases like malaria, hepatitis, cancers, and inflammations. Objective: Determine of antimalarial and anti-protozoa effects of A. anuuae and C. bo...