UNLABELLED Phyllomedusine frogs are an extraordinary source of biologically active peptides. At least 8 families of antimicrobial peptides have been reported in this frog clade, the dermaseptins being the most diverse. By a peptidomic approach, integrating molecular cloning, Edman degradation sequencing and tandem mass spectrometry, a new family of antimicrobial peptides has been identified in ...

This study provide an up-to-date overview of the epidemiology and risk factors for Candida bloodstream infection in Scotland in 2012/2013, and the antifungal susceptibility of isolates from blood cultures from 11 National Health Service boards within Scotland. Candida isolates were identified by chromogenic agar and confirmed by MALDI-TOF methods. Survival and associated risk factors for patien...

Candida albicans is a dimorphic fungus that colonizes human mucosal surfaces with the potential to cause life-threatening invasive candidiasis. Studies on systemic candidiasis in a murine infection model using in vivo real-time bioluminescence imaging revealed persistence of C. albicans in the gall bladder under antifungal therapy. Preliminary analyses showed that bile conferred resistance agai...

This scoping review aims to summarise the current understanding of selection for antifungal resistance (AFR) and compare contrast this with antibacterial resistance, which has received more research attention. AFR is an emerging global threat human health, associated high mortality rates, absence effective surveillance systems few alternative treatment options available. Clinical well documente...

OBJECTIVE To establish whether there has been any rise in the prevalence of non-albicans Candida species isolated from vaginal swabs since the introduction of "over the counter" antifungal treatments. METHOD A retrospective review looking at all positive vaginal yeast isolates collected from women attending one genitourinary medicine clinic during the 6 year period from 1993 to 1998 inclusive...

Abstract Cow milk is a highly nutritious food but many factors predispose it to microbial contamination. There paucity of information on antifungal-resistant pathogens. Hence the study investigated fungi from fresh cow samples and their resistance some antifungals. Twenty-seven (27) were isolated forty-three ( n =43) PDA (Potato dextrose agar) media, re-cultured in glucose yeast extract broth, ...