Antidepressant use and new-onset diabetes: a systematic review and meta-analysis. Diabetes Metab Res Rev 2013;29:273–84. 19. Kivimäki M, Batty GD, Jokela M et al. Antidepressant medication use and risk of hyperglycemia and diabetes mellitus: a noncausal association? Biol Psychiatry 2011;70:978–84. 20. Mezuk B, Johnson-Lawrence V, Lee H et al. Is ignorance bliss? Depression, antidepressants, and...

BACKGROUND Despite the prevalence of depression in the elderly, there is a shortage of randomized controlled studies comparing the efficacy of various antidepressant classes in this population. OBJECTIVES This review of recent data on the treatment of depression in the elderly examined the relative efficacy of the selective serotonin reuptake inhibitors (SSRIs) and 2 antidepressant classes ha...

the antidepressant effects of aloe vera hydro alcoholic extract at different concentrations were compared with the fluoxetine-treated and the control groups of mice using forced - swimming, fst and open box, oft tests. the mice were evaluated in five groups (control, taking aloe vera at the dosage levels of 150 mg/kg, 300 mg/kg, and 450 mg/kg, and finally fluoxetine at a dose of 10 mg/kg) by th...

OBJECTIVE To examine the efficacy and safety of short-term and long-term use of antidepressants in the treatment of bipolar disorder. DATA SOURCES A literature search of randomized, double-blind, controlled trials published until December 2012 was performed using the PubMed, ISI Web of Science, Medline and Cochrane Central Register of Controlled Trials databases. The keywords "bipolar disorde...

BACKGROUND In the United States, there is a disparity in knowledge of nationwide depression prevalence, the antidepressant use and the antidepressant responses during perinatal/postpartum periods. OBJECTIVE This study investigated the predicting factors of depression, antidepressant use and positive antidepressant response during the perinatal/postpartum periods. METHOD The 2007-2012 Nation...

The complex relationship between the use of antidepressants and suicidal behaviour is one of the hottest topics of our contemporary psychiatry. Based on the literature, this paper summarizes the author's view on antidepressant-resistant depression and antidepressant-associated suicidal behaviour. Antidepressant-resistance, antidepressant-induced worsening of depression, antidepressant-associate...

moclobemide is a selective and reversible monoamine oxidase-a inhibitor, which is used as an antidepressant. three moclobemide analogues were synthesized by replacing moclobemide phenyl ring with substituted imidazoles. so, n-[(4-morpholinyl) ethyl)]-1-benzyl-2-(alkylthio)-1h-imidazole-5-carboxamides (7a-c) were synthesized and studied for the antidepressant activity using forced swimming test ...

the net analyte signal standard addition method was used for simultaneous spectrophotometric determination of sertraline and fluoxetine in pharmaceutical preparations. the method combines the advantages of the standard addition method with the net analyte signal concept to enable the extraction of information about an analyte from the spectra of multi-component mixtures. this method uses full s...

Depression is one of the most common psychiatric disorders that may result in significant consequences in active population of the society. In traditional manuscripts there are many indications about the antidepressant effects of rose oil, but so far no scientific research has been done about this subject. The purpose of present study was to determine the antidepressant effects of rose oil and ...

A pooled analysis of randomized placebo controlled antidepressant trials shows that the rate of antidepressant and placebo responders are 50% and 30% respectively. The traditional calculation of drug-placebo difference (50-30=20%) in these drug-trials is based on the assumption that all placebo responders should be antidepressant responders. However, it seems to be not the case, since about one...