Microglia activation results in release of proinflammatory molecules including cytokines, which contribute to neuronal damage in the central nervous system (CNS) if not controlled. Tetracycline antibiotics such as minocycline inhibit microglial activation and cytokine expression during CNS inflammation. In the present study we found that administration of chemically modified tetracycline-3 (COL...

Various antibacterial factors in saliva have been demonstrated 2,1"2 la but none seem to have been isolated. A "lytic" agent in saliva and a purified lysozyme from eggwhite seem similar in their effect on Micrococcus Iysodeikticus,"9"' although the two have been shown to be immunologically distinct.10 Inasmuch as separation of protein elements in saliva, by means of paper electrophoresis, has b...

Methods The present study involved the synthesis of gold nanoparticles using a sodium cholate, as both reducing and capping agent and characterization by UVVisible spectroscopy and High ResolutionTransmission Electron Microscopy (HRTEM). The antibacterial activity on significant bacterial species was evaluated by micro broth dilution method. The mechanism for antibacterial action of the gold na...

Fresh flowers of Allamanda Cathartica Linn. were collected and was extracted with 90% methanol under reflux. The alcoholic extract was concentrated in vacuo and the aqueous concentrate was fractionated with benzene, peroxide free diethylether and ethylacetate successively. The ethyl acetate fraction was concentrated in vacuo and left in an ice chest for a few days. The yellow solid obtained, a ...

Lagenandra ovata (Linn.) Thw. syn. L. toxicaria Dalz. of Araceae family was evaluated for antibacterial activity against the Gram positive bacterium, Staphylococcus aureus and the Gram negative bacteria, Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, P. vulgaris and Pseudomonas aeruginosa. Methanol extract of the rhizome and the oil fractions obtained from the methanol extract thro...

Seven-membered heterocyclic [1,2,5]triazepane and [1,2,5]oxadiazepane derivatives were synthesized as candidate structures for application in drug discovery in place of conventional piperazine or morpholine moieties, offering multiple sites for modification with functional groups. We first synthesized the N-protected heterocycles, and then confirmed their utility by synthesizing analogues of th...

Antibacterial air filter media offer an important solution to indoor pollution from bioaerosols, which pose a serious threat global public health. In this study, we introduced antibacterial based on nanofibers functionalized with photothermal agent, deactivates bacteria upon near-infrared (NIR) irradiation. Halloysite nanotube (HNT) clay nanoparticles coated polydopamine (PDA), heat up when exp...