نتایج جستجو برای: antiacetyl cholinesterase

تعداد نتایج: 4737  

Journal: :Journal of psychopharmacology 2011
John T O'Brien Alistair Burns

The British Association for Psychopharmacology (BAP) coordinated a meeting of experts to review and revise its first (2006) Guidelines for clinical practice with anti-dementia drugs. As before, levels of evidence were rated using accepted standards which were then translated into grades of recommendation A to D, with A having the strongest evidence base (from randomized controlled trials) and D...

Journal: :Okajimas folia anatomica Japonica 1963
K YASUDA H MACHIDA T SUZUKI

Tne distribution or cnonnesterase in tne numan sion nas been studied by several investigators, with particular attention to the nerve fibers around the sweat gland (H u r le y, Shelly and Koelle, 1953, Hellmann, 1955, and Montagna and Ellis, 1958). No cholinesterase-positive nerve fibers have been found around the apocrine sweat gland by these investigators, even though a physiological examinat...

2003
ABRAHAM MAZUR

cholinergic effects of the fluorophosphates and those of physostigmine was noted by the British workers, McCombie et al.,’ and by Adrian and his group.2 The theory of chemical mediation of the transmission of nerve impulses through the autonomic nervous system identifies ac&ylcholine as the mediator. The presence of the enzyme, cholinesterase, at sites where acetylcholine is liberated by the ne...

Journal: :The Journal of biological chemistry 1946
O BODANSKY A MAZUR

cholinergic effects of the fluorophosphates and those of physostigmine was noted by the British workers, McCombie et al.,’ and by Adrian and his group.2 The theory of chemical mediation of the transmission of nerve impulses through the autonomic nervous system identifies ac&ylcholine as the mediator. The presence of the enzyme, cholinesterase, at sites where acetylcholine is liberated by the ne...

2003
THOMAS L. LENTZ

To determine the effects of nerve explants on the integrity of motor end plates in vitro, cholinesterase activity and structure of end plates were compared in newt muscle denervated in vivo, cultured in the absence of nerve explants, and cultured in the presence of sensory ganglia . In neuromuscular junctions denervated in vivo or in vitro, the synaptic vesicles become clumped and fragmented . ...

2008
HELMUT NIEDERHOFER

Mukadam et al. (2008) report cholinesterase inhibitors to be effective in treating delirium. This suggests that cholinesterase inhibitors have a broader spectrum of effect than the treatment of dementia alone. Acetylcholine itself interacts with various other neurotransmitters. Cancelli et al. (2004) report that a fall in acetylcholine levels, as occurs in dementia, could increase sensitivity t...

Journal: :Clinical science 2004
Faisel Khan Gwen Kennedy Vance A Spence David J Newton Jill J F Belch

In the present study, we have investigated whether the peripheral cholinergic abnormalities that we have reported previously [Spence, Khan and Belch (2000) Am. J. Med. 108, 736-739] in patients with chronic fatigue syndrome (CFS) are also present in those with Gulf War syndrome (GWS) and agricultural workers exposed to organophosphate pesticides, where cholinesterase inhibition is specifically ...

Journal: :Pharmacology, biochemistry, and behavior 1997
M A Kronforst-Collins P L Moriearty M Ralph R E Becker B Schmidt L T Thompson J F Disterhoft

The cholinergic system is known to show deterioration during aging and Alzheimer's disease. In response, a therapeutic approach to Alzheimer's disease has been to attempt to compensate for the decrease in central cholinergic function by potentiating the activity of the remaining intact cholinergic cells with cholinesterase inhibitors. In this study treatment with the long-lasting cholinesterase...

2009
Natarajan Suganthy Shunmugiahthevar Karutha Pandian Kasi Pandima Devi

Dementia is a chronic progressive mental disorder, which adversely affects memory, thinking, comprehension, calculation and language. Some of the most common dementias are Alzheimer’s disease, Parkinsonism, Dementia with Lewy Bodies and Myasthenia gravis. All of these disorders are related to abnormalities in the central cholinergic system, which shows a decline in acetylcholine (ACh) level due...

2012
Marc L. Gordon Peter B. Kingsley Terry E. Goldberg Jeremy Koppel Erica Christen Lynda Keehlisen Nina Kohn Peter Davies

AIM To characterize progression of Alzheimer's disease (AD) using proton magnetic resonance spectroscopy ((1)H MRS). METHODS Eleven subjects with mild to moderate AD underwent neurocognitive testing and single-voxel (1)H MRS from the precuneus and posterior cingulate region at baseline, after 24 weeks of monotherapy with a cholinesterase inhibitor, and after another 24 weeks of combination th...

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