نتایج جستجو برای: anti ulcer agents

تعداد نتایج: 710879  

Journal: :Pharmacological reviews 2015
Pertti Panula Paul L Chazot Marlon Cowart Ralf Gutzmer Rob Leurs Wai L S Liu Holger Stark Robin L Thurmond Helmut L Haas

Histamine is a developmentally highly conserved autacoid found in most vertebrate tissues. Its physiological functions are mediated by four 7-transmembrane G protein-coupled receptors (H1R, H2R, H3R, H4R) that are all targets of pharmacological intervention. The receptors display molecular heterogeneity and constitutive activity. H1R antagonists are long known antiallergic and sedating drugs, w...

Journal: :Gut 1987
C Manniche A Malchow-Møller J R Andersen C Pedersen T M Hansen P Jess L Helleberg S N Rasmussen U Tage-Jensen S E Nielsen

Sixty-seven patients with rheumatic disease, treated with non-steroidal anti-inflammatory drugs (NSAIDs), entered a controlled trial with a diagnosis of duodenal (n = 51), gastric (n = 14), or gastric and duodenal (n = 2) ulcers. The main objectives of the study were a comparison of ranitidine and sucralfate in ulcer treatment, and to observe the influence of continued NSAID administration duri...

Journal: :Antimicrobial agents and chemotherapy 2002
Suping Jiang Juliana Meadows Steven A Anderson Antony J Mukkada

The benzimidazole compound omeprazole, used widely for the treatment of peptic ulcer disease, inhibits the growth of Leishmania donovani, the causative agent of visceral leishmaniasis. Promastigotes cultured at acidic pH and amastigotes within infected macrophages are reduced 90% or more with 150 microM omeprazole. Antiparasitic action of the drug is due to its inhibition of the P-type K(+),H(+...

Journal: :The Yale Journal of Biology and Medicine 1997
Fred Halter K.D. Rainsford Steven P. Sirko Adrian Schmassmann

Introduction: Some non-steroidal anti-inflammatory drugs (NSAIDs) delay healing of experimental gastric ulcers. The two experimental NSAIDs tebufelone and nitrofenac exert relatively low ulcerogenicity in various animal models compared with conventional NSAIDs. In addition, it has been reported that nitrofenac accelerates experimental acute ulcer healing. However, the effects of these new NSAID...

Journal: :Alimentary pharmacology & therapeutics 2001
J M Scheiman R R Bandekar M E Chernew A M Fendrick

INTRODUCTION Although it is incontrovertible that Helicobacter pylori causes peptic ulcer disease, controversy persists regarding the impact of H. pylori infection on the incidence of NSAID-related complications and whether H. pylori eradication reduces the rate of adverse events. METHODS A symptom-driven decision analytic model was developed to compare the clinical and economic impact of H. ...

2017

Peptic ulcer disease prevalence is decreasing in the West, except in certain populations such as immigrants. [2] A UK population-based cohort study reported an overall incidence of uncomplicated peptic ulcer as being 0.75 cases per 1,000 person-years, declining from 1.1 to 0.52 cases per 1,000 person-years between 1997 and 2005. A reduction in H. pylori-related peptic ulcers, changing patterns ...

Journal: :Annali italiani di chirurgia 2013
Domenico Parmeggiani Marco Apperti Luigi Goffredi Nicola Avenia Imma Madonna Pasquale Ambrosino Roberto Peltrini Sarah Apperti Andrea Fiore Umberto Parmeggiani

OBJECTIVE To test the usefulness of silver dressings in patients with skin ulcers in the healing phase after debridement. MATERIALS AND METHODS After randomly selected a group of 30 patients and divided them into three groups (A, B and C) according to the type and severity of the ulcer, we used respectively for each group antiseptics-free dressings, hydrofiber dressings with a low or a high c...

Journal: :مجله دانشگاه علوم پزشکی شهید صدوقی یزد 0
شکوه تقی پور ظهیر sh taghipour zahir هنگامه زندی h zandi ضیاء الله بوترابی z botorabi ناهید مرات n merat

introduction: glycyrrhiza glabra (licorice) root, a member of the pea family has been used since ancient times as both food and medicine. licorice has been used as an antioxidant, antimicrobial and anti inflammatory in researches .extraction of this medical plant is used as the basis of anti-ulcer medicine for treatment of peptic ulcer. patients and methods: in the present study, licorice decoc...

Journal: :Helicobacter 2003
Javier P Gisbert José María Pajares

Although the role of Helicobacter pylori infection on noncomplicated peptic ulcer disease has been definitively established, the precise relationship between the organism and complicated ulcer has hardly been studied. The mean prevalence of H. pylori infection in patients with perforated peptic ulcer is of only about 65-70%, which contrasts with the almost 90-100% figure reported in noncomplica...

Journal: :British medical journal 1987
D A Henry A Johnston A Dobson J Duggan

Although non-steroidal anti-inflammatory drugs are known to cause peptic ulcer and its complications, controversy exists about the number of deaths from ulcer which are attributable to their use. A case-control study was therefore performed to determine whether prior use of non-steroidal and other anti-inflammatory compounds was associated with an increased case fatality rate from complications...

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