The present study compares the efficacy of two formulations of encapsulated streptokinase to streptokinase in a rabbit model of carotid artery thrombosis. Arterial thrombosis followed the injection of thrombin mixed with autologous whole blood into a carotid artery of New Zealand white rabbits. Thirty minutes after the confirmation of an occlusive thrombus, one of four streptokinase formulation...

Inhibitors of fibrinolysis may be divided into naturally circulating inhibitors and antifibrinolytic agents. Natural inhibitors are present in plasma and are components of blood cells, especially platelets. Several types of antifibrinolytic activity can be distinguished: antiplasmin activity, and anti-activator activity against streptokinase, urokinase, and tissue activator induced plasminogen ...

Chemical immunotherapeutic strategies including Antibody Recruiting Molecules (ARMs - bivalent small molecules containing an antibody-binding domain (ABD) and a target-binding (TBD)) direct immune-mediated clearance of diseased cells. Anti-cancer ARM function relies on high tumor antigen valency, limiting against lower expressing tumors. To address this limitation, we report tunable multivalent...

conclusions thyroid dysfunction was not higher in sle patients compared to healthy individuals. however, anti-tg antibodies were higher in sle patients. it has not yet been established that thyroid function tests should be performed routinely in sle patients. results the mean age of sle patients and controls were 32.16 ± 9.19 and 32.48 ± 9.47 years, respectively (p = 0.821). patients had signif...

background & aims: mistyping either a donor or a recipient can lead to transfusion with abo incompatible blood which results in severe intravascular hemolysis and may even result in the death of the recipient. abo phenotype is one of the essential tests in immunohematology. eighty percent of blood group a and ab persons are subtype a1 and a1b, respectively. the other 20% of these blood groups a...

conclusions according to the results, it was found that hcv high prevalent genotype in zanjan is subtype 3a. analysis of the results provides identification of certain hcv genotypes, and these valuable findings could affect the type and duration of the treatment. results samples indicated 216 bp bands on 2% agarose gel. analyses of the results demonstrated that the most dominant subtype was 3a ...

Acute myocardial infarction (AMI) is one of the main leading causes of mortality and morbidity. Despite the progress in the treatment of AMI, streptokinase is still being used in many countries. Because of the critical condition of patients with AMI and complications of streptokinase therapy, this study was performed to evaluate the pattern of adverse drug reaction (ADRs) induced by streptokina...

The costs and benefits of early thrombolytic treatment with intracoronary streptokinase in acute myocardial infarction were compared in a randomised trial. All hospital admissions were recorded and the functional class was assessed at visits to the outpatient clinic during a 12 month follow up of 269 patients allocated to thrombolytic treatment and of 264 allocated to conventional treatment. Me...

The aim of this study was to explore the chronergy of intravenous recombinant streptokinase (r-SK) in patients with acute myocardial infarction (AMI). A total of 114 patients were divided into two groups according to the time of AMI onset: the morning onset (6:01-12:00, n=53) and non-morning onset (12:01-06:00, n=61) groups. The recanalization rate was recorded, as well as anticoagulant and fib...