background: hepatitis b infection is a major public health problem worldwide. given that immune response towards the vaccine is not perfect, we aimed to evaluate circumstances of immune response in vaccinated students. materials and methods: in this study, 219 medical students of ardabil university of medical sciences were recruited, who had been administered vaccine series for the first time, ...

Streptococcus pneumoniae is the leading cause of bacterial meningitis. Pneumococcal meningitis is a life-threatening disease with high rates of mortality and neurological sequelae. Immune targeting of S. pneumoniae is essential for clearance of infection; however, within the brain, the induced inflammatory response contributes to pathogenesis. In this study we investigate the local inflammatory...

type i diabetes mellitus (dm) is frequently associated with autoimmune thyroid disease (atd). association of atd and type i dm has been described with varying frequencies but there is still debate about the situation in the iranian population. we investigated the prevalence of anti thyroid peroxidase (anti-tpo) antibodies and atd in children and adolescents with type i dm. a total of 145 patien...

introduction: leukocytes causing a wide variety of side effects after transfusion are present in all blood products prepared by standard methods. as a consequence, the use of filter technology for leukoreduction has been widely practiced .according to aabb accreditation in 1996, leukoreduced blood components must contain less than 5×106 leukocytes per unit, but sometimes this value is higher ev...

about 8% of the general population suffers from autoimmune diseases, from which 78% are women. one of the most important causes of thyroid diseases is autoimmunity in origin, and it seems that people with thyroid diseases present more signs of asthma. this study was therefore designed to investigate the frequency of autoimmune thyroid diseases in women suffering from bronchial asthma. in a cros...

background: in lupus nephritis (ln), deposition of pathogenic autoantibodies in the glomeruli is mediated via cross-reactivity with alpha-actinin. association of serum alpha-actinin antibody (aαa) with ln has been shown in a few studies but the results are controversial. methods: eighty patients into entered the study. the diagnosis of sle was confirmed according to the american college of rheu...

background: immunopathological and inflammatory processes play important roles in the initiation and development of ischemic heart disease (ihd). objective: the aim of this study was to evaluate the serum levels of several autoantibodies including rheumatoid factor (rf), anti-nuclear antibodies (ana), anti-small nuclear ribonucleoprotein (anti-sm), anti-phosphatidylserine (anti-ps) and anti-car...

background: auto antibodies to zona-pellucida (aza) seem to be important autoantibodies implicated in reproduction, with substantial role in both endocrine and reproductive functions of the human ovary. there are some debates on the relation of aza with infertility, repeated in vitro fertilization (ivf) attempts, and outcome of it. objective: in this study, we assessed the presence of aza in th...

BACKGROUND Otitis media with effusion (OME) is very common during childhood. Because Streptococcus pneumoniae is one of the most common bacterial pathogens involved in OME, pneumococcal vaccines may have a role in the prevention of recurrent OME. OBJECTIVE We sought to assess the effect of combined pneumococcal conjugate and polysaccharide vaccinations on the recurrence of OME. METHODS A ra...

BACKGROUND Pneumococcal conjugate vaccines are important for the prevention of serious illness and death among infants. Factors associated with pneumococcal conjugate vaccine immunogenicity have not been explored. METHODS Children <24 months of age received 2, 3, or 4 doses of 7-valent pneumococcal conjugate vaccine (PnCRM7) or control vaccine depending on age at enrollment. Serum samples wer...