introduction : regular blood transfusions for patients with thalassemia major have improved their overall survival, but carry a definite risk of being infected with blood born viruses especially hepatitis b and c. nowadays, it has remained as main health concern about these patients. in this study, we tried to define the prevalence rate of hepatitis b and c and survey the related risk factors a...

This study explores the methodology of various experimental vaccines and their immunogenicity outcome in detail. The idea is to give to the reader a picture of the research methodology behind vaccine development that was used in this research. The novelty of this study bases on the demonstration of the cause and effect of antibodies produced against bacterial and viral proteins (immunogens) as ...

HIV/AIDS is an increasingly important cause of cardiovascular (CVD) morbidity world-wide. We sought to evaluate the prevalence CVD risk factors in HIV positive (HIV+) adults and assessment these risks using Framingham score (FRS). A cross-sectional study adult clients clinic at Jos University Teaching Hospital. One hundred fifty HIV+ selected randomly with 50 (age sex matched) negative (HIV-) p...

predictive quantitative structure–activity relationship was performed on the novel 4-oxo-1,4-dihydroquinoline and 4-oxo-4h-pyrido[1,2-a]pyrimidine derivatives to explore relationship between the structure of synthesized compounds and their anti-hiv-1 activities. in this way, the suitable set of the molecular descriptors was calculated and the important descriptors using the variable selections ...

Background: Serious treatment associated adverse events are thought to occur more frequently in individuals with tuberculosis (TB) who are co-infected with HIV. A study was undertaken to assess the frequency of serious (grade III/IV) adverse events and interruption of anti-TB treatment in the era of effective antiretroviral therapy. Methods: The incidence of serious adverse events was retrospec...

MicroRNAs (miRNAs), the post-transcriptional regulators of gene expression, play key roles in modulating many cellular processes. The changes in the expression profiles of several specific miRNAs affect the interactions between miRNA and their targets in various illnesses, including addiction, HIV, cancer etc. The presence of anti-HIV-1 microRNAs (which regulate the level of infectivity of HIV-...

Type III interferons (IFN-λs) have been demonstrated to inhibit a number of viruses, including HIV. Here, we further examined the anti-HIV effect of IFN-λs in macrophages. We found that IFN-λs synergistically enhanced anti-HIV activity of antiretrovirals [azidothymidine (AZT), efavirenz, indinavir, and enfuvirtide] in infected macrophages. Importantly, IFN-λs could suppress HIV infection of mac...

hemophiliac patients carry a high risk for blood born viruses particularly hepatitis c virus (hcv) infection. with introducing the new therapeutic modalities for hiv infection, the role of hcv in mortality and morbidity has been more prominent. hiv co-infection is a wellknown factor that accelerates the progression of liver injury leading to end stage liver failure. screening of hemophiliacs ha...

Human immunodeficiency virus-type I (HIV-1) infection elicits antibodies (Abs) directed against several regions of the gp120 and gp41 envelope glycoproteins. Many of these Abs are able to neutralize T-cell-line-adapted strains (TCLA) of HIV-1, but only a few effectively neutralize primary HIV-1 isolates. The nature of HIV-1 neutralization has been carefully studied using human monoclonal Abs (M...