Elevated levels of inflammatory markers, such as C-reactive protein, are well documented in people with depression. Few studies have examined whether the association between inflammation and depression is symptom specific, and differs according to antidepressant treatment. Using data from the English Longitudinal Study of Ageing (N=5909), cross-sectional analyses revealed a significant dose-res...

Meta-Chlorophenylpiperazine (m-CPP), a serotonin agonist and metabolite of the anti-depressant trazodone, was administered chronically to eight moderate to severely affected Alzheimer patients to determine whether it would produce improvement in behavioral symptoms complicating this illness. In doses up to 80 mg/day for 16 days, m-CPP was well tolerated and resulted in small but significant inc...

Smoking cessation aids (nicotine replacement products and anti-depressant medication) have been proven to double quitting rates compared to placebo in several randomized controlled trials. But the high initial cost of cessation aids might create a financial barrier to cessation for low-income smokers. In the U.S., Medicaid provides health insurance coverage to low-income people, and in some sta...

OBJECTIVE The present study was undertaken to evaluate anti-depressant activity of Myristica fragrans (MS). MATERIALS AND METHODS Male Wistar rats were subjected to imipramine and herbal extract of MS for their antidepressant activity using Forced Swimming Test (FST), Reserpine Reversal Test (RRT), Haloperidol-Induced Catalepsy (HIC), and Pentobarbitone Sleeping Time (PST). RESULTS Administ...

OBJECTIVE To formulate guidelines for diagnosis and management of depressive illness in general practice in Pakistan. METHODS Using guidelines developed through research in primary care, this article explains how depressive illness could be diagnosed using diagnostic and statistical manual (DSM) criteria and managed systematically at general practice level in Pakistan. RESULTS Diagnosing de...

The ethanolic leaf extract of Cymbidium aloifolium (L.) was intended to evaluate the effect on the central nervous system (CNS) using a number of neuropharmacological experimental models in mice. The extract, at the dose of 200 and 400 mg/kg body weight, were shown to have CNS depressant activity by the reduction of locomotor and exploratory activities in the open field and hole cross tests. Th...

In the present study, microflotation experiments were performed on pure minerals systems involving hematite and quartz in presence of etherdiamine as collector. The influence polyacrylamides co-depressant was investigated a blend with starch depressant. results obtained demonstrated that all used efficient depression, at different levels following order effectiveness: cationic > non-ionic anion...

A patient treated with venlafaxine for major depression developed an interstitial lung disease (ILD) with the characteristic clinical, radiological and pathological features of chronic hypersensitivity pneumonitis. A high resolution computed tomography scan demonstrated ground glass opacity, mosaic perfusion with air-trapping and traction bronchiectasis in both lungs. The pathological findings ...