Resumen El ácido linoleico conjugado (CLA) es un ácido graso que pertenece al grupo de los ácidos grasos poliinsatura-dos, representado por el conjunto de isómeros del ácido linoleico, que son denominados conjugados porque poseen una doble conexión tras uma conexión simple. Dentre sus isómeros se distinguen el trans-10,cis-12 y cis-9, cis-12 CLA. Estos isômeros son capaces de promover efectos d...

Objective: Chronic obstructive pulmonary disease (COPD) is characterized by systemic inflammation and accelerated inflammaging of the lungs. Some studies showed that conjugated linoleic acid (CLA) has anti-inflammatory effects. The aim of the present study was to evaluate the effect of CLA supplementationon serum levels of interleukin (IL)-6 and sirtuin1 (SIRT1) in patients wit...

BACKGROUND Trans fatty acids are produced either by industrial hydrogenation or by biohydrogenation in the rumens of cows and sheep. Industrial trans fatty acids lower HDL cholesterol, raise LDL cholesterol, and increase the risk of coronary heart disease. The effects of conjugated linoleic acid and trans fatty acids from ruminant animals are less clear. We reviewed the literature, estimated th...

BACKGROUND Conjugated linoleic acid (CLA) has been extensively studied for decades because of its health benefits including cancer prevention, anti-atherogenic and anti-obesity effects, and modulation of the immune system. We previously described the production of trans-10, cis-12 CLA in Yarrowia lipolytica by expressing the gene coding for linoleic acid isomerase from Propionibacterium acnes (...

We examined the effect of dietary conjugated linoleic acid (CLA) on liver regeneration after a partial hepatectomy (PH) in Sprague-Dawley rats. PH was performed on rats fed a 0 or 1 wt.% CLA diet for 3 wk. Average liver weight in the CLA fed rat population was heavier than the control rat population at the time of PH and 1-d after PH. Conversely. CLA fed rats' liver weight was significantly low...

Conjugated linoleic acid (CLA) and CLA isomers, present naturally in dairy meat products, are the natural functional components. Ruminal microorganisms, such as Butyrivibrio fibrosolvens, lactic bacteria (LAB), propionibacteria can convert (LA) to CLA. In this study, effect of different concentrations (0, 0.5, 1, 2%) storage time 2, 7, 14 21 days) on content kefir was investigated. The highest ...

This study assessed the effects of combined chromium picolinate (CP) and conjugated linoleic acid (CLA) supplementation on energy restriction and exercise-induced changes in body composition, glucose metabolism, lipid lipoprotein profile and blood pressure in overweight, premenopausal women. For 12 weeks, 35 women [age 36+/-1 years (mean+/-S.E.M.); BMI 28.0+/-0.5 kg/m2] were counseled to consum...

Previous research suggested that conjugated linoleic acid (CLA) feeding during the period of pubescent mammary gland development in the rat resulted in diminished mammary epithelial branching which might account for the reduction in mammary cancer risk. Terminal end buds (TEB) are the primary sites for the chemical induction of mammary carcinomas in rodents. One of the objectives of the present...

The definition of trans-fatty acids (TFA) was established by the Codex Alimentarius to guide nutritional and legislative regulations to reduce TFA consumption. Currently, conjugated linoleic acid (CLA) is excluded from the TFA definition based on evidence (primarily preclinical studies) implying health benefits on weight management and cancer prevention. While the efficacy of CLA supplements re...

Fatty acids containing trans unsaturated double bonds occur in nature, but the most common dietary source are “man-treated” fats. Because of the possible link between trans-fatty acids consumption and human disease-mainly cardiovascular disease and cancer, the health effects of trans-FA have been studied for over the last fifty years. Trans fatty acids are unsaturated fatty acids with at least ...