Objective(s): Systemic lupus erythematosus (SLE) is a multi-factorial autoimmune disease which may be characterized by T lymphocytes dysfunctions. Th17 cells have been identified as new effector cells, which play an important role in the pathogenesis. In recent years, immunomodulatory effect of vitamin D3 has been noticed. In the present experiment, the effect of vitamin D3 on the expression of...

Background: Cerebral sinovenous thrombosis (CSVT) is a neurovascular disorder that occurs when a blood clot develops in a vein near the brain. Evaluating the subsequent changes in inflammatory cytokines can better reveal the underlying pathogeneses. Objective: To assess the serum levels of interleukin-10 (an anti-inflammatory cytokine) and IL-17 (a pro-inflammatory cytokine) in patients with as...

Objective(s): It is now supposed that cytokines released during the burn injuries have a great impact on the immunological and pathological responses after the burn. The main objective of this study was to investigate the expression of some pro-inflammatory genes in the wound, spleen and blood neutrophils during the healing process of burn wounds in a murine model. Materials and Methods: The ex...

background the immune system plays important roles in determining the outcomes of hepatitis c virus (hcv) infection. interleukin-23 and -27 (il-23 and il-27) are two novel il-12 cytokine family members known to enhance the t-lymphocyte response, but their precise involvement in hcv infection is not well known. objectives we investigated the serum il-27 and il-23 levels in patients with hcv infe...

Background: Cesarean section delivery can lead to much maternal morbidity. Different cytokines have been reported to be influenced by the mode of delivery. Objective: To investigate the influence of mode of delivery on maternal, placental and cord sera of interferon gamma (IFN-γ), interleukin-4 (IL-4) and interleukin-10 (IL-10) levels. Methods: These three cytokines were measured using ELISA in...

background: il-17/il-23 axis plays an important role in the pathogenesis of several autoimmune diseases such as experimental autoimmune encephalomyelitis (eae) and multiple sclerosis (ms). the immunomodulatory properties of ginger are reported in previous studies. objective: to evaluate the effects of ginger extract on the expression of il-17 and il-23 in a model of eae. methods: eae was induce...

allergic asthma is a multifactorial disease, influenced by genetic and environmental factors. recent family-based studies have revealed evidence for linkage of human chromosomes 5q31-33, 12q15-24, 11q13 and 15q23.6 as regions likely to contain genes related to asthma. among the candidate genes in these regions are the genes encoding for human interleukin-4, interleukin-13 and interleukin-16. to...

patients and methods in total, 98 samples in four groups (hiv-positive and hiv-negative persons with and without oc) were obtained from the oral cavities and cultured on sabouraud’s dextrose agar and chromagar. also blood samples were obtained to assess plasma level of ifn-γ, il-4, il-6 and il-17 using elisa technique. background cell-mediated immunity (cmi) by cd4 + th (t helper)-type cells is...