Nuclear pore complexes (NPCs) provide the sole gateway for the exchange of material between nucleus and cytoplasm of interphase eukaryotic cells. They support two modes of transport: passive diffusion of ions, metabolites and intermediate-sized macromolecules, and facilitated, receptor-mediated translocation of proteins, RNA, and RNPs complexes. It is generally assumed that both modes of transp...

1) From the Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA 2) Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 10115, USA 3) present address: Kavli Institute of NanoScience, Department of BioNanoScience, Technical University Delft, Lorentzweg , 2628 CJ Delft, The Netherlands 4) present address: De...

ATP-BINDING CASSETTE TRANSPORTER A1 MEDIATES THE BENEFICIAL EFFECTS OF THE LIVER-X-RECEPTOR AGONIST GW3965 ON OBJECT RECOGNITION MEMORY AND AMYLOID BURDEN IN APP/PS1 MICE James J. Donkin, Sophie Stukas, Veronica Hirsch-Reinshagen, Dhananjay Namjoshi, Anna Wilkinson, Sharon May, Jeniffer Chan, Jianjia Fan, Jon Collins, and Cheryl L. Wellington From Department of Pathology and Laboratory Medicine...

The reading for Friday’s class is a seminal wireless research paper. What makes this paper especially interesting experimentally is that while it is astoundingly careful, deep, and complete, ultimately one of the major conclusions of the paper turns out to be incorrect. Furthermore, this error is due to a mistake in the experimental methodology. This document explains the error and provides eno...

Snail1 and Zeb1 are E-cadherin-transcriptional repressors induced during epithelialmesenchymal-transition (EMT). In this article we have analyzed the factors controlling Zeb1 expression during EMT. In NMuMG cells treated with TGF-β, Snail1 RNA and protein are induced one hour after addition of the cytokine preceeding Zeb1 up-regulation that requires six to eight hours. Zeb1 gene expression is c...

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We investigated the renal response to direct renal nerve stimulation, 2 weeks following reversal of 24-hr unilateral (left) ureteric obstruction. Renal nerve stimulation caused a 13-15% fall in renal blood flow, in 4 groups of anaesthetised rats following ureteric obstruction (n=9) or a sham operation (n=7) both with (n=9) and without (n=7) treatment with the mixed ETA/B receptor antagonist, bo...

We thank Schimek for his thoughtful letter. We agree that the American Association of State Highway and Transportation Officials (AASHTO) encourages bike paths; however, AASHTO’s definition of a bike path is a shared use path for pedestrians, skaters, wheelchair users, joggers, and other nonmotorized users. AASHTO discourages bicycle-only cycle tracks because, as noted by Schimek, AASHTO discou...

1 1 2 3 4 5 6 Distinctive receptive field and physiological properties of a wide-field amacrine cell in the macaque 7 monkey retina 8 9 10 Michael B. Manookin, Christian Puller, Fred Rieke, Jay Neitz, Maureen Neitz 11 Department of Ophthalmology, Physiology and Biophysics Department, HHMI, University of 12 Washington, Seattle, WA 98109 13 14 Corresponding authors: Michael B. Manookin (manookin@...

This research compares the role of initial individual characteristics to that of patterns of resolution in which successive dominance relationships are established during the formation of triads in the domestic hen. Combining weight, prior victory or defeat in the site of encounter, and comb size, we created three levels of asymmetries on characteristics for triads of hens. The effects of these...