The present work was focused on the development and characterization of new hydrogel systems based on natural origin polymers, namely, alginate and carrageenan, into different formats and with adequate properties to sustain the viability of encapsulated cells, envisioning their application as cell delivery vehicles for tissue regeneration. Different formulations of alginate and carrageenan hydr...

The search for newer non-steroidal antiinflammatory drugs (NSAIDs) and the importance of oxadiazoles as antiinflammatory agents prompted us to undertake the synthesis of some novel oxadiazole and related analogues with unreported antiinflammatory activities. The antiinflammatory potential of the compounds was investigated using the carrageenan-induced rat paw edema method and cotton pellet-indu...

Carrageenan produces both inflammation and pain when injected in mouse paws via enhancement of reactive oxygen species formation. We have investigated an effect of astaxanthin extracted from Litopenaeus vannamei in carrageenan-induced mice paw edema and pain. The current study demonstrates interesting effects from astaxanthin treatment in mice: an inhibition of paw edema induced in hind paw, an...

The aim of present study was to investigate the effect of trifluoperazine (TFP) on carrageenan-induced rat's paw edema in intact and adrenalectomized (ADX). TFP (0.2 and 8 mg/kg) were given intraperitoneally just before the intraplantar injection of 0.1 ml of 0.5% carrageenan solution. After four hours, paw edema was assessed by calculating the paw volume changes and extravasations of Evans blu...

In recent years, several marine-derived compounds have been clinically evaluated. Diterpenes are secondary metabolites from soft coral that exhibit anti-inflammatory, anti-tumor and cytotoxic activities. In the present study, we isolated a natural diterpene product, excavatolide B, from cultured Formosan gorgonian Briareum excavatum and investigated its anti-inflammatory activities. We found th...

This study aimed to evaluate Helychrisum faradifani hydro alcoholic extract activity on the vascular and cellular phases of inflammation in mice. Carrageenan was injected hind-paw effect edema acetic acid 0.6 % by intra peritoneal route H. permeability. Cotton pellets imbibed with 1% carrageenan inserted skin animals investigate granuloma formation. Indomethacin at dose 10 mg/kg administered or...

The present investigation deals with the in-vivo acute toxicity studies and in-vivo anti-inflammatory activity by Carrageenan induced rat paw edema model of methanolic extract in the stems of Cissus Vitiginea. The Literature review reveals the presence of steroids, flavonoids, triterpenoids, and glycosides in Cissus Vitiginea. Some plants belonging to Cissus genus have been reported to possess ...

herbal medicines are playing a vital role in the remedy of numerous diseases. preliminary phytochemical screening of the methanolic extracts of seeds (mnls) and peel (mnlp) of nephelium longan revealed the presence of alkaloids, tannins and flavonoids. for antidairrheal screening, we have followed castor-oil-induced method whereas to check anti-inflammatory property, we used carrageenan-iduced ...

Colonic mucosal lesions, characterized by crypt abscesses and mononuclear cell infiltration, which resemble human ulcerative colitis can be induced in rabbits by short-term (7 to 8 weeks) administration of carrageenan according to our method. In this study experimental epithelial dysplasia of the colon was induced by the p.o. administration of lambda-degraded carrageenan for a much longer perio...

Many species of Teucrium were used traditionally in treatment of inflammatory disorders. The present study aimed to assess the anti-inflammatory effect of methanolic extract of aerial parts of Teucrium oliverianum Ging. ex. Benth. (family, Lamiaceae). The extract was evaluated using the carrageenan-induced rat paw edema (Acute and sub-acute models), and turpentine oil–induced granuloma pouch bi...