There is considerable evidence that pregnancy changes the disposition of drugs in an enzymeand gestational stage–specific manner. On the basis of probe drug studies, the activity of CYP3A4 and CYP2D6 increases and CYP1A2 decreases during human pregnancy. However, no studies of CYP2B6 activity during human pregnancy have been conducted. In rodent models and in HepG2 cells, CYP2B enzymes have bee...

There is considerable evidence that pregnancy changes the disposition of drugs in an enzymeand gestational stage–specific manner. On the basis of probe drug studies, the activity of CYP3A4 and CYP2D6 increases and CYP1A2 decreases during human pregnancy. However, no studies of CYP2B6 activity during human pregnancy have been conducted. In rodent models and in HepG2 cells, CYP2B enzymes have bee...

We present the design of the simulation package Pluto, aimed at the study of hadronic interactions at SIS and FAIR energies. Its main mission is to offer a modular framework with an object-oriented structure, thereby making additions such as new particles, decays of resonances, new models up to modules for entire changes easily applicable. Overall consistency is ensured by a pluginand distribut...

Observations have resolved the satellite Charon from its parent planet Pluto, giving separate spectra of the two objects from 1.0 to 2.5 micrometers. The spectrum of Charon is found to be different from that of Pluto, with water ice in crystalline form covering most of the surface of the satellite. In addition, an absorption feature in Charon's spectrum suggests the presence of ammonia ices. Am...

Prevailing role of intracellular amyloid β (iAβ) in Alzheimer’s disease (AD) initiation and progression attracts more and more attention in recent years. To address whether iAβ induces early alterations of electrophysiological properties in cultured human primary neurons, we delivered iAβ with adenovirus and measured the electrophysiological properties of infected neurons with whole-cell record...

Near the inner edge of the Edgeworth-Kuiper Belt (EKB) are Pluto and Charon, which are known to have N2and H2O-dominated surface ices, respectively. Such non-polar and polar ices, and perhaps mixtures of them, also may be present on other trans-Neptunian objects. Pluto, Charon, and all EKB objects reside in a weak, but constant UV-photon and energetic ion radiation environment that drives chemi...

Although Single Instruction Multiple Data (SIMD) units are available in general purpose processors already since the 1990s, state-of-the-art compilers are often still not capable to fully exploit them, i.e., they may miss to achieve the best possible performance. We present a new hardware-aware and adaptive loop tiling approach that is based on polyhedral transformations and explicitly dedicate...