BACKGROUND Diurnal fluctuation of bile acid (BA) concentrations in the enterohepatic system of mammals has been known for a long time. Recently, BAs have been recognized as signaling molecules beyond their well-established roles in dietary lipid absorption and cholesterol homeostasis. METHODS AND RESULTS The current study depicted diurnal variations of individual BAs detected by ultra-perform...

Business associations (BAs) represent a widely prevalent institution contingent upon a plethora of regional and industrial contexts around the world. Although their role in local development is rarely highlighted this paper argues that analysis of the structure and strategies of BAs reveals important insights into the problematic nature of external economies, typically based on the willingness ...

Novelty seeking and harm avoidance are two major temperamental dimensions from the Cloninger's biosocial model of personality that are theoretically related to Gray's behavioral approach system (BAS) and behavioral inhibition system (BIS), respectively. The revised version of the temperament and character inventory (TCI-R) and the Carver and White BIS/BAS scales were developed to assess these c...

The relationship between BA (bile acid) secretion (measured by GC-MS) and the expression of genes (measured by reverse transcription real-time PCR) involved in liver BA transport and metabolism was investigated at 20 and 32 weeks during rat hepatocarcinogenesis. A progressive loss of mRNA for transporters (more marked for Ntcp, Bsep and Mrp2 than for Oatp1/Oatp1a1, Oatp2/Oatp1a4 and Oatp4/Oatp1...

This study examined the relationship between reinforcement sensitivity theory (RST), life stress, and internalizing symptoms. Generally, low sensitivity of the behavioral approach system (BAS) predicts depression whereas high sensitivity of the behavioral inhibition system (BIS) predicts anxiety and depression. However, few studies have examined how RST variables interact with life stress to pr...

The current study aimed to investigate the potential protective role of boswellic acids (BAs) against doxorubicin- (DOX-) induced hepatotoxicity. Also, the possible mechanisms underlying this protection; antioxidant, as well as the modulatory effect on the Nrf2 transcription factor/hem oxygenase-1 (Nrf2/HO-1) pathway in liver tissues, was investigated. Animals were allocated to five groups: gro...

Frankincense preparations, used in folk medicine to cure inflammatory diseases, showed anti-inflammatory effectiveness in animal models and clinical trials. Boswellic acids (BAs) constitute major pharmacological principles of frankincense, but their targets and the underlying molecular modes of action are still unclear. Using a BA-affinity Sepharose matrix, a 26-kDa protein was selectively prec...

Investigators commonly distinguish between primary and secondary psychopathy (H. Cleckley, 1976; D.T. Lykken, 1995), though there is a lack of consensus regarding the best means to achieve this distinction. To address the validity of using R. D. Hare's (2003) Psychopathy Checklist and the G. Welsh (1956) Anxiety Scale for this purpose, the authors used 2 measures of J. A. Gray's (1987) behavior...

INTRODUCTION The transvaginal bone anchored polypropylene sling (BAS) has proven to be a successful treatment for patients with SUI. However, there is limited data on long-term outcomes following BAS with polypropylene mesh. We report our series of patients who had at least 3 years of follow-up after placement of BAS. MATERIALS AND METHODS A retrospective review of prospectively collected dat...

the hoard of kalmakarra cave that includes hundreds of golden and silver objects has been unearthed in 1989 in pol-e dokhtar located at loristān province by villagers. in addition to aesthetical values, these objects bear archeological significance. their unique value, with respect to inscriptions in old aramaic, neo- assyrian and neo- elamite on some of them. deciphering these inscriptions by ...