Abstract Introduction Clomiphene citrate (CC), a selective estrogen receptor modulator, and anastrozole, aromatase inhibitor, are common empiric medical therapies for men with idiopathic infertility. The effects of jointly administering these agents not well understood. Objective objective this study is to compare semen parameters in treated clomiphene anastrozole (CC-A) combination therapy tho...

Although the use of endocrine therapy in combination with intravenous chemotherapy has not been standardized, the combination of fulvestrant and chemotherapy may be promising. A 62-year-old woman came to our hospital's outpatient clinic with extensive ascites. Approximately 10 years earlier, she had undergone mastectomy and sentinel lymph node biopsy. Pathologically invasive lobular carcinoma, ...

Gnant et al. presented the final results of the Austrian Breast and Colorectal Cancer Study Group Trial 12 (ABCSG-12) trial after a median follow-up of 94.4 months [1]. Although there was no disease free survival (DFS) difference between patients who received ovarian function suppression (OFS) plus either tamoxifen or anastrozole, patients treated with anastrozole + OFS had a significantly wors...

Gnant et al. presented the final results of the Austrian Breast and Colorectal Cancer Study Group Trial 12 (ABCSG-12) trial after a median follow-up of 94.4 months [1]. Although there was no disease free survival (DFS) difference between patients who received ovarian function suppression (OFS) plus either tamoxifen or anastrozole, patients treated with anastrozole + OFS had a significantly wors...

Anastrozole (Arimidex), letrozole (Femara), and exemestane (Aromasin) are members of the third generation of aromatase inhibitors that has now replaced aminoglutethimide (Cytadren), the progestins, and tamoxifen (Nolvadex) as the hormonal therapy of choice in estrogen-receptor-positive, postmenopausal, metastatic breast cancer. This article will review the role of aromatase in the pathogenesis ...

Aromatase is an enzyme that converts testosterones to estrogens. Inhibition of this enzyme has been shown to have several clinical utilities in breast cancer. Currently, there are three aromatase inhibitors (AIs) in clinical use, namely anastrozole, letrozole, and exemestane. AIs have been used in various clinical settings for breast cancer, ranging from chemoprevention in breast cancer to trea...

BACKGROUND Perforation of the gall bladder as a first presentation of breast cancer has not been reported. CASE PRESENTATION Here we present a case of an elderly lady with acute abdomen with evidence of possible perforation of gall bladder on CT scan. Histopathology of the cholecystectomy specimen revealed invasive lobular breast cancer.Her metastatic breast cancer with right sided primary di...