نتایج جستجو برای: anaplastic thyroid carcinoma
تعداد نتایج: 458435 فیلتر نتایج به سال:
Introduction: Diffusely enlarged giant thyroid glands are becoming increasingly infrequent. However, in some geographical areas they are still relatively common. Anaplastic thyroid carcinoma is rare but is an aggressive and lethal malignancy. Since it is associated with severe complications, surgical treatment of giant goiter requires a high level of expertise. Material and Methods: Herein, a c...
Here, we show that the anaplastic thyroid carcinoma (ATC) features the up-regulation of a set of genes involved in the control of cell cycle progression and chromosome segregation. This phenotype differentiates ATC from normal tissue and from well-differentiated papillary thyroid carcinoma. Transcriptional promoters of the ATC up-regulated genes are characterized by a modular organization featu...
BACKGROUND Anaplastic thyroid carcinoma (ATC), accounting for 5% to 15% of primary malignant thyroid neoplasms, is one of the most aggressive solid tumors in humans. Generally, it is rapidly fatal, with a mean survival of six months after diagnosis. Multimodality treatment with surgery and/or external beam radiotherapy and chemotherapy are of fundamental importance for local control of disease ...
Anaplastic thyroid carcinoma (ATC) is one of the most malignant human neoplasms and has a grave prognosis. This study gives an update on our experience with this unusual neoplasm, with specific focus on the response to various treatment modalities. Forty-seven patients with histologically proven ATCs were enrolled (19 men, 28 women; mean age, 62.8 years). This number represents 1.5% among a tot...
Periostin is an extracellular matrix protein. Five isoforms of human periostin cDNA have been reported, but the expression of periostin isoforms in the human thyroid tissue is by far unknown. A group of primer sets were designed to amplify the full length of cDNA sequence of periostin. Using human thyroid carcinoma and their paired non-neoplastic tissues together with anaplastic thyroid carcino...
OBJECTIVE Although anaplastic thyroid carcinoma has a dismal prognosis, some patients show favorable survival following multimodal treatment with surgery, external irradiation and chemotherapy. However, no regimen has yet been established. We reviewed outcomes for patients who underwent a unique chemoradiotherapy regimen between 1998 and 2007. METHODS The regimen consists of external irradiat...
Anaplastic thyroid carcinoma [ATC] is a rare highly malignant tumor that arises from the follicular cells of the thyroid gland. It accounts for 1% to 2% of all thyroid carcinomas and uniformly have a poor prognosis. patterns; these 3 subtypes frequently coexist and they are not predictive of the patient Patients often present at an advanced stage, making curative surgical resection not feasible...
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