Twenty-two patients with advanced solid tumors were treated with a quinazoline folate antagonist, trimetrexate, to determine the toxicity spectrum, the maximal tolerated dose, and the pharmacokinetics of the drug. Negligible toxicity was seen with single doses of 10-70 mg/m2 given as a 1-h infusion. Single doses of 120 mg/m2 infused over 1 h caused moderate to grade 4 toxicity in five of nine p...

A simple spectrophotometric method for determination of glucosamine release from sustained release (SR) hydrophilic matrix tablet based on reaction with ninhydrin is developed, optimized and validated. The purple color (Ruhemann purple) resulted from the reaction was stabilized and measured at 570 nm. The method optimization was essential as many procedural parameters influenced the accuracy of...

In recent years, governmental pressure on reducing the cost of drugs, together with the growth in the number of generic manufacturers, have given a considerable boost to competition in the pharmaceutical sector. Such relevant market change has highlighted the necessity of controlling and improving performance in order to reduce costs while maintaining high qualitylevels, both enhancing working ...

Fragility curves for retrofitted bridges indicate the influence of various retrofit measures on the probability of achieving specified levels of damage. This paper presents an analytical methodology for developing fragility curves for classes of retrofitted bridge systems. The approach captures the impact of retrofit on the vulnerability of multiple components, which to date has not been adequa...

Markey and Abramson [1] developed a microwave-powered chemical reaction interface, a device which converts a complex organic molecule in the presence of a reactant gas into small stable molecules which are detected by mass spectrometry. For a given reactant gas the molecules formed are a representation of the elemental composition of the original anlayte. The combination of the reaction interfa...

In this paper we propose an analytical approach for estimating the reliability of a component-based software. This methodology assumes that the software components are heterogeneous and the transfers of control between components follow a discrete time Markov process. Besides, we also formulate and solve two resource allocation problems. Finally, we demonstrate how these analytical approaches c...

Abstract: In this article, an approximate analytical solution of coupled nonlinear equations with fractional time derivative are obtained with the help of approximate analytical method of nonlinear problem called the Homotopy Perturbation Method. By using initial condition, the explicit solutions of the coupled equation have been derived which demonstrate the potentiality, validity, effectivene...

Studies of the occurrence, distribution and aqueous geochemistry of arsenic in the environment requires accurate and sensitive analytical measurements. In addition to the determination of total arsenic concentrations, speciation of the form in which arsenic occurs plays a major role in its chemical reactivity and toxicity. Determination of speciation includes: the distribution of oxidation stat...