نتایج جستجو برای: amyloid β
تعداد نتایج: 204360 فیلتر نتایج به سال:
A simple in vitro biosensor for the detection of β-amyloid 42 in phosphate-buffered saline (PBS) and undiluted human serum was fabricated and tested based on our platform sensor technology. The bio-recognition mechanism of this biosensor was based on the effect of the interaction between antibody and antigen of β-amyloid 42 to the redox couple probe of K₄Fe(CN)₆ and K₃Fe(CN)₆. Differential puls...
Amyloid-β and α-synuclein are intrinsically disordered proteins (IDPs), which are at the center of Alzheimer's and Parkinson's disease pathologies, respectively. These IDPs are extremely flexible and do not adopt stable structures. Furthermore, both amyloid-β and α-synuclein can form toxic oligomers, amyloid fibrils and other type of aggregates in Alzheimer's and Parkinson's diseases. Experimen...
Nearly all adults with Down syndrome show neuropathology of Alzheimer's disease, including amyloid-β deposition, by their fifth decade of life. In the current study, we examined the association between brain amyloid-β deposition, assessed via in vivo assessments of neocortical Pittsburgh compound B, and scores on an extensive neuropsychological battery of measures of cognitive functioning in 63...
A FRET-based sensor protein presenting amyloid-like structures was successfully constructed for detecting the oligomeric assemblies of amyloid β-peptide (Aβ) wild-type and FAD-related mutants.
A receptor that incites cell suicide also promotes the accumulation of β-amyloid plaques in Alzheimer's disease (AD), as He et al. show on page 829. In mice prone to the brain buildups, eliminating the receptor cut the number of plaques and spared memory. The results point to new treatments for the incurable disease. As plaques of β-amyloid collect in the brains of AD patients, large numbers of...
Background AD (Alzheimer’s disease) is the prime causes for 65-85% cases of senile dementia occurs due to plaques aggregation and tangles formation in various parts brains neurons (cortical hippocampal) leading brain cell death. The major cause extracellular accretion made β-amyloid protein. β-secretase enzyme also known as BACE-1 key player behind this phenomenon catalyzing rate determining st...
Amyloid-β deposition in Alzheimer's disease is thought to start while individuals are still cognitively unimpaired and it is hypothesized that after an early phase of fast accumulation, a plateau is reached by the time of cognitive decline. However, few longitudinal Pittsburgh compound B-positron emission tomography studies have tested this hypothesis, and with conflicting results. The purpose ...
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