A novel electrochemically controlled release method for nitric oxide (NO) (based on electrochemical reduction of nitrite ions) is combined with an amperometric oxygen sensor within a dual lumen catheter configuration for the continuous in vivo sensing of the partial pressure of oxygen (PO2) in blood. The on-demand electrochemical NO generation/release method is shown to be fully compatible with...

A cuprous oxide (Cu2O) thin layer served as the base for a non-enzymatic glucose sensor in an alkaline medium, 0.1 NaOH solution, with a linear range of 50-200 mg/dL using differential pulse voltammetry (DPV) measurement. An X-ray photoelectron spectroscopy (XPS) study confirmed the formation of the cuprous oxide layer on the thin gold film sensor prototype. Quantitative detection of glucose in...

We report fabrication of a microneedle-based three-electrode integrated electrochemical sensor and in-vitro characterization of this sensor for glucose sensing applications. A piece of silicon was sequentially dry and wet etched to form a 15 × 15 array of tall (approximately 380 µm) sharp silicon microneedles. Iron catalyst was deposited through a SU-8 shadow mask to form the working electrode ...

A molecularly imprinted electrochemical sensor for determination of isoamyl alcohol was successfully constructed by modifying the glassy carbon electrode (GCE) with gold nanoparticles (AuNPs) and reduced graphene oxide (RGO). The modification GCE increased electron transfer rate surface area, which, consequently, made more room available formation polymer (MIP). development MIP on modified carr...

Here we report on the optimisation of a reagentless enzyme sensor for the detection of azide based on the mediated reduction of O2 by a laccase enzyme co-immobilised in a redox hydrogel on electrode surfaces. The sensor response is shown to be influenced by the enzyme loading, the electrolyte pH and ionic strength. The response of the sensor is stable, decreasing by only 25% over a sixteen-hour...

OBJECTIVE Needle-implantable sensors have shown to provide reliable continuous glucose monitoring for diabetes management. In order to reduce tissue injury during sensor implantation, there is a constant need for device size reduction, which imposes challenges in terms of sensitivity and reliability, as part of decreasing signal-to-noise and increasing layer complexity. Herein, we report sensit...