congenital recessive myotonia is a rare genetic disorder caused by mutations in clcn1, which codes for the main skeletal muscle chloride channel clc-1. more than 120 mutations have been found in this gene. the main feature of this disorder is muscle membrane hyperexcitability. here, we report a 59-year male patient suffering from congenital myotonia. he had transient generalized myotonia, which...

background toxoplasma gondii is an obligatory intracellular protozoan parasite, which infects human beings. since the current antigens used for diagnosis or vaccination are contaminated with non parasitic material in which the parasite is grown, it is tried to produce recombinant antigens to design vaccines against toxoplasmosis, or make diagnostic kits. choosing the type of antigen to produce ...

background: the over-expression of recombinant proteins in large amount is important for production of therapeutic proteins and structural study. there are several systems for expression of recombinant proteins. one of the most relevant expression systems is escherichia coli (e. coli). although this organism has many advantages, most of recombinant proteins expressed in e. coli hosts form inclu...

in recent years there have been many attempts to develop and market inexpensive mixtures of high protein food for the children in developing areas of the world. biological studies have shown that these foods are rich sources of protein and are every effective in combating protein malnutrition. however, practical marketing and distribution has not been very successful due to the local people's h...

methods in this study, 150 children diagnosed with liver disease and ascites upon admission to nemazee teaching hospital (shiraz, iran) were examined. patients were divided into spontaneous bacterial peritonitis and sterile ascetic fluid groups according to the pmn count ≥ 250/mm3 in the ascetic fluids. routine laboratory tests were conducted and quantitative c-reactive protein (crp) levels wer...

introduction: binding a monoclonal antibody to tumor associated antigens is an effective method for cancer therapy because these agents can specifically target malignant cells, in fact monoclonal antibodies are effective agents for diagnosis, grading and treatment of different kinds of cancers. methods: in this research, a new monoclonal antibody against colon cancer cells was prepared and anti...

mehg and total mercury concentrations were determined in the muscle tissues of four fish species (cyprinus carpio, rutilus frisii, carassius auratus and esox lucius) from anzali wetland (guilan, iran). fish with the highest amount of mehg was selected to determine the thermodynamic parameters of mehg extraction. the extractions process was performed in the range of temperatures 331.15 to 367.15...

background: protein-protein interactions do not provide any direct information re­garding the domains within the proteins that mediate the interactions. the majority of proteins are multi domain proteins and the interaction between them is often defined by the pairs of their domains. most of the former studies focus only on interacting do­main pairs. however they do not consider the interaction...

Tobacco mosaic virus (TMV) is one of the devastating plant viruses in the world that infects more than 200 plant species. Movement protein plays a supportive role in the movement of other plant viruses, and viral coat protein is highly expressed in infected plants and affects replication and movements of TMV. In order to investigate genetic variation in the terminal fragment sequence in Iranian...