Abbreviations MLC micellar liquid chromatography FDA food and drug analysis 2 Abstract A simple and robust method was developed for the routine identification and quantification of amoxicillin by micellar liquid chromatography. Amoxicillin, a β-lactamase inhibitor, is one of the most commonly prescribed drugs in the treatment of urine and skin structure infections. In this work, amoxicillin was...

Received: 24 Nov 2014 Accepted: 12 May 2015 Abstract Background and Aim: Some researchers have attempted to enhance the antibacterial properties of sealers by addition of antibiotics while this may affect their physical properties. The purpose of this in vitro study was to compare the working time and flow of AH Plus sealer alone and in combination with amoxicillin and triple antibiotic paste (...

Pharmaceutical suspension containing oral dosage forms delivering both immediate-release and sustained-release amoxicillin was developed as a new dosage form to eradicate Helicobacter pylori. Amoxicillin-loaded gelatin nanoparticles are able to bind with the mucosal membrane after delivery to the stomach and could escalate the effectiveness of a drug, providing dual release. The objective of th...

The important role of Helicobacter pylori (H. pylori) in idiopathic duodenal ulcer disease is widely acknowledged. Treatment with amoxicillin and omeprazole has been highly successful in eradicating H. pylori in some pilot studies. We conducted a study in patients with active duodenal ulcer disease and H. pylori colonization of gastric mucosa using a combination of amoxicillin and lansoprazole....

Methods/results Recently we evaluated a 48 years old woman for a long lasting suspected multiple drug hypersensitivity. Patient’s medical story was characterized by a proved reflux esophagitis, HP infection, and GERD symptoms that were persistent for over 8 years. During the previous 5 years, different treatments of HP infection based on Amoxicillin, Levofloxacin, and Clarithromycin had induced...

The discovery of Helicobacter pylori (H. pylori) provided a possibility to cure effectively patients with peptic ulcers. Recent studies have shown varying susceptibility of H. pylori strains to antibiotics and increasing resistance to some of the recommended drugs. The purpose of the present study was to evaluate the efficacy of the currently recommended eradication schemes and to assess the in...

The discovery of Helicobacter pylori (H. pylori) provided a possibility to cure effectively patients with peptic ulcers. Recent studies have shown varying susceptibility of H. pylori strains to antibiotics and increasing resistance to some of the recommended drugs. The purpose of the present study was to evaluate the efficacy of the currently recommended eradication schemes and to assess the in...

BACKGROUND The prevalence of resistance to clarithromycin and metronidazole has considerably increased, with a corresponding decrease in the eradication rate for Helicobacter pylori (H. pylori) infection. Primary resistance to amoxicillin is extremely low, and esomeprazole was found to exert a noteworthy antimicrobial activity in vitro against H. pylori. A dual therapy with high-dose of esomepr...

The effects of patient age on the efficacy of eradication treatment for Helicobacter pylori (H. pylori) remain unclear. The present study aimed to determine whether age affects eradication therapy involving vonoprazan, a novel potassium-competitive acid blocker (PCAB). We reviewed the cases of 3,261 patients who were administered first-line and second-line H. pylori eradication therapy at Toyos...

OBJECTIVES To investigate the bactericidal activity against Streptococcus pneumoniae of simulated amoxicillin serum concentrations obtained in humans after 2000/125 mg sustained-release (SR) and 875/125 mg co-amoxiclav administered twice and three times a day, respectively. METHODS An in vitro computerized pharmacodynamic simulation was carried out and colony counts were determined over 24 h....