Oral delivery of poorly water-soluble compounds is often a substantial challenge. Once a drug candidate is selected, it is desirable to predict, based on chemical structure, which formulation technology has the highest potential to enhance drug solubility and absorption. Due to the importance of amorphous drug formulations, this work aimed at calculating the solubility ratio of amorphous and cr...

Phase transformations in the supercooled liquid region (between T, and T,,,), prior to the onset of crystallization, in amorphous Pd-Ni-P alloys remain controversial. It has been previously proposed that the amorphous alloy decomposes into two amorphous phases prior to the crystallization reaction when annealed in the supercooled liquid region. Investigations by DSC, Mossbauer spectroscopy, X-r...

Introduction: Soils on Mars have been analyzed by the Mars Exploration Rovers (MER) and most recently by the Mars Science Laboratory (MSL) rover. Chemical analyses from a majority of soil samples suggest that there is a relatively uniform global soil composition across much of the planet [1]. A soil site, Rocknest, was sampled by the MSL science payload including the CheMin X-ray diffractometer...

Swift heavy ion (SHI) irradiation of conventional glasses results in non-saturable plastic flow as a consequence of the ion hammering effect [1]. SHI irradiation of amorphous Si (a-Si) at non-perpendicular incidence also leads to unsaturated plastic flow, which shows a linear dependence on the ion fluence. The positive direction of flow suggests that a liquid phase with density similar to that ...

The preparation of stable amorphous pemetrexed disodium of pharmaceutical purity as well as the process optimization for the preparation of the hemipentahydrate form of pemetrexed disodium are described. Analytical methods for the polymorphic and chemical purity studies of pemetrexed disodium and pemetrexed diacid forms were developed. The physicochemical properties of the amorphous and hydrate...

Fly ash samples from the five steam electric power stations of the Lignite Center of Western Macedonia were used in this study. They consisted mainly of anhydrite, lime, quartz and amorphous material as well as feldspars, calcite, micas + clays, portlandite and gehlenite which were all present in minor amounts. Anhydrite, lime and portlandite in the fly ash samples diminished upon treatment wit...

Recently amorphous MoS2 thin film has attracted great attention as an emerging material for electrochemical hydrogen evolution reaction (HER) catalyst. Here we prepare the amorphous MoS2 catalyst on Au by atomic layer deposition (ALD) using molybdenum hexacarbonyl (Mo(CO)6) and dimethyl disulfide (CH3S2CH3) as Mo and S precursors, respectively. Each active site of the amorphous MoS2 film effect...

Arsenic adsorption on amorphous aluminum and iron oxides was investigated as a function of solution pH, solution ionic strength, and redox state. In this study in situ Raman and Fourier transform infrared (FTIR) spectroscopic methods were combined with sorption techniques, electrophoretic mobility measurements, and surface complexation modeling to study the interaction of As(III) and As(V) with...

Variable-amplitude oscillatory shear tests are emerging as powerful tools to investigate and quantify the nonlinear rheology of amorphous solids, complex fluids, and biological materials. Quite a few recent experimental and atomistic simulation studies demonstrated that at low shear amplitudes, an amorphous solid settles into an amplitude- and initial-conditions-dependent dissipative limit cycl...