Mycobacterium tuberculosis has enjoyed the distinction, among the nonspore bearing organisms, of being one of the most resistant to chemical disinfection. Quaternary ammonium compounds, widely used as effective germicides against gram positive organisms, have generally proved to be without effect on the tubercle bacillus (Lawrence and Grover, 1951; Smith et al., 1950). Recently, it has been rep...

We previously reported the complete sequence of the resistance plasmid pP10164-NDM, harboring blaNDM (conferring carbapenem resistance) and bleMBL (conferring bleomycin resistance), which is recovered from a clinical Leclercia adecarboxylata isolate P10164 from China. This follow-up work disclosed that there were still two multidrug-resistant (MDR) plasmids pP10164-2 and pP10164-3 coexisting in...

OBJECTIVES Cetylpyridinium chloride (CPC), a quaternary ammonium compound, was shown to interact irreversibly with Streptococcus mutans biofilms, leading to a slow diffusion compared with poly(ethylene glycol) (PEG) molecules of similar size. The objective of this work is to determine if the retardation of CPC diffusion and its strong binding to biofilms is caused by interactions between the am...

Anion exchange of BF(4)(-) occurs by stirring a cobalt(III) complex of salen-type ligand tethered by four quaternary ammonium BF(4)(-) salts over a slurry of NaX in CH(2)Cl(2), affording a complex containing four X's per cobalt (X = 2,4,5-trichlorophenolate, 6; X = 4-nitrophenolate, 10; X = 2,4-dichlorophenolate, 12). The (1)H and (13)C NMR spectra are in agreement with an unusual imine uncoord...

The standard molar enthalpy of combustion (Δc H (o) m) and formation (Δf H (o) m) of quaternary ammonium tetrachlorozincate [n-CnH2n+1N(CH3)3]2ZnCl4 have been determined for the hydrocarbon chain length from even number 8 to 18 of carbon atoms (n) by an oxygen-bomb combustion calorimeter. The results indicated that the values of Δc H (o) m increased and Δf H (o) m decreased with increasing chai...

dodecapeptide 5 does not seem to follow this trend, which may suggest that secondary interactions exist between the terpenoid and peptide moieties. Although we still need to perform many experiments to develop a reliable mechanistic model to explain the observed phenomenon, our preliminary observations show an interesting potential in this area and investigation along this line is in progress i...

Calix[4]arene derivatives supported on monolayer protected gold clusters show a remarkable enhanced binding efficiency towards quaternary ammonium salts in homogeneous solution of apolar solvents with respect to the corresponding unsupported hosts.