Fasting blood glucose was determined in 27 adults with essential hypertension at four different periods during a 12-month treatment with doxazosin, an alpha-adrenoceptor antagonist, and in another set of 20 adult hypertensive patients, after 3 months treatment with amlodipine, a calcium antagonist. The mean fasting blood glucose levels at various determinations during doxazosin therapy did not ...

OBJECTIVES We examined whether amlodipine, a calcium channel antagonist with potent antioxidant activity, inhibits doxorubicin-induced apoptosis in cultured neonatal rat cardiac myocytes. BACKGROUND Recent studies have shown that doxorubicin induces apoptosis as well as necrosis in myocytes through generation of reactive oxygen species. METHODS The effects of amlodipine and several other an...

BACKGROUND Antihypertensive drugs are used to control blood pressure (BP) and reduce macro- and microvascular complications in hypertensive patients with diabetes. OBJECTIVES The present study aimed to compare the functional vascular changes in hypertensive patients with type 2 diabetes mellitus after 6 weeks of treatment with amlodipine or losartan. METHODS Patients with a previous diagnos...

Clopidogrel is a prodrug that has to be converted in vivo to its active metabolite by cytochrome (CYP)P450 iso-enzymes. As calcium channel blockers (CCBs) are inhibitors of CYP3A4, concomitant use of these drugs might play a role in the wide inter-individual variability in the response to clopidogrel. However, some CCBs also have strong inhibitory effects on the drug transporter P-glycoprotein ...

BACKGROUND High glucose concentration, through the activation of calcium channels, augments in vitro calcium entry into cells and leads to elevation in the basal levels of [Ca2+]i, the latter causes cell dysfunction. DESIGN OF STUDY The present study examined whether streptozotocin-induced diabetes mellitus in rats causes a rise in [Ca2+]i of PMNL and impairs their phagocytosis and whether tr...

Background: A quick and thoughtful liquid chromatography–tandem mass spectrometry (LC-MS) method has been established and authorized for the estimation of amlodipine and atorvastatin in human plasma. Methods: LC-MS with electrospray ionization (ESI) interface in positive ion mode was functioned under the multiplereaction monitoring (MRM) mode was used for detection of analytes. Ethyl acetate wa...

Hypertension is a leading cause of death and disability in the United States worldwide. As primary care clinicians, nurse practitioners help patients control their blood pressure through lifestyle coaching medication. Among first-line medications for hypertension are calcium channel blockers, such as amlodipine. In US, over 70 million prescriptions amlodipine written annually. Here we present c...

BACKGROUND In the treatment of hypertension in subjects of African origins, although hydrochlorothiazide (HCTZ) is not as effective as calcium channel blockers, indapamide is superior to HCTZ. In the present study we therefore compared the effects of slow release (SR) indapamide with the calcium channel blocker amlodipine, when used as initial therapy, on blood pressure (BP) and left ventricula...

BACKGROUND Type 2 diabetes is a complex metabolic disorder characterized by hyperglycemia, impaired glucose tolerance and insulin resistance associated with dyslipidemia and hypertension. The available drugs are not sufficiently efficacious in reducing cardiovascular risk and restoring normal glucose metabolism associated with type 2 diabetes as a mono- or a combination therapy. The present stu...

Objective: To compare the efficacy and the effect of the oxidative stress of Calcium Channel Blocker (CCB), Amlodipine and Angiotensin Converting Enzyme (ACE) inhibitor, Ramipril in the hypertensive patients of North East India. Methods: It is a prospective randomized controlled parallel study of the clinically used antihypertensive drug. Total 75 subjects were included in the study. Out of 75 ...