A galactoglucomannan oligosaccharide (GGMO) obtained from fiberboard production was evaluated as a dietary supplement for dogs. The GGMO substrate contained increased concentrations of oligosaccharides containing mannose, xylose, and glucose, with the mannose component accounting for 35% of DM. Adult dogs assigned to a 6 × 6 Latin square design were fed 6 diets, each containing a different conc...

We have developed a novel high-throughput screening platform for the discovery of small-molecules catalysts for bond-forming reactions. The method employs an in vitro selection for bond-formation using amphiphilic DNA-encoded small molecules charged with reaction substrate, which enables selections to be conducted in a variety of organic or aqueous solvents. Using the amine-catalysed aldol reac...

We report on preparing assemblies of gold nanoparticles with continuous gradients in number density on flat silica-covered substrates. The methodology consists of (i) first forming a one-dimensional molecular gradient of amino groups (-NH2) on the substrate by vapor deposition of amine-terminated silane molecules, followed by (ii) attachment of gold nanoparticles to -NH2 functional groups by im...

Palladium catalysed coupling reactions on haloporphyrins have revolutionised the functionalisation of the porphyrin periphery. There are now many and varied examples of successful C–C and C–X couplings, expecially on the meso positions(s) of 5,15-diarylor 5,10,15-triarylporphyrins, to produce a range of functionalised mononuclear derivatives, as well as diand oligonuclear arrays with alkynyl, a...

A broad spectrum of possible functions of Cu-AOs, ranging from cell adhesion, cell growth regulation, to clinical applications are described. Their action may be related to the control of H 2 O 2 levels as they are reported to be inactivated by the same H 2 O 2 they produce, upon prolonged exposure to amine in excess over oxygen. This was demonstrated in pea seedling and pig kidney amine oxidas...

Molecular wires comprising a Ru(II)- or Re(I)-complex head group, an aromatic tail group, and an alkane linker reversibly inhibit the activity of the copper amine oxidase from Arthrobacter globiformis (AGAO), with K(i) values between 6 muM and 37 nM. In the crystal structure of a Ru(II)-wire:AGAO conjugate, the wire occupies the AGAO active-site substrate access channel, the trihydroxyphenylala...

SidA from the human pathogen Aspergillus fumigatus catalyzes the generation of N(5)-hydroxyornithine in the biosynthesis of siderophores, a reaction essential for virulence. The crystal structures of SidA in complex with ornithine and lysine reveal the geometry of the interactions among flavin, NADP(+), and the substrate amine group that underlie the hydroxylation reaction. The structural eluci...

DNA micropatterns have been fabricated on the surface of Polycarbonate (PC) bases of compact discs, with the ultimate goal of using conventional CD technology for DNA analysis. To confirm the formation of -COOH groups on the PC surface upon UV/ ozone treatment, contact angle titrations were carried out on the PC surfaces. The surface morphologies of PC surface were measured by Tapping-mode Atom...

The aluminium amide Al(NMe2)3 acts as a stoichiometric or catalytic reagent in dehydrogenic Si-N bond formation using amines and silanes. Although of limited substrate scope, this represents the first p-block metal catalytic system for N-H/Si-H dehydrocoupling. The observed catalytic rate law for the formation of aminosilane products in a model study of one of the catalytic reactions suggests a...

Conductance across a metal|molecule|metal junction is strongly influenced by the molecule-substrate contacts, and for a given molecular structure, multiple conductance values are frequently observed and ascribed to distinct binding modes of the contact at each of the molecular termini. Conjugated molecules containing a trimethylsilylethynyl terminus, -C≡CSiMe(3) give exclusively a single conduc...