I N a now classic article, Rosen and associates1 described an alveolar filling disease which they named pulmonary alveolar proteinosis. This disorder is of unknown origin and usually occurs as a primary process, although it may also be seen in association with hematologic neoplasms.2 In alveolar proteinosis the distal air spaces become filled with a lipoproteinaceous material that has chemical ...

Kohut, M. L., J. M. Davis, D. A. Jackson, P. Jani, A. Ghaffar, E. P. Mayer, and D. A. Essig. Exercise effects on IFN-b expression and viral replication in lung macrophages after HSV-1 infection. Am. J. Physiol. 275 (Lung Cell. Mol. Physiol. 19): L1089–L1094, 1998.—Mice exercised to fatigue and exposed to herpes simplex virus type 1 (HSV-1) exhibit greater mortality than control mice. In this st...

Cytospin preparations of mononuclear inflammatory cells were made from bronchoalveolar lavage fluid obtained from 15 patients with interstitial lung disease (nine patients with sarcoidosis and six patients with cryptogenic fibrosing alveolitis) and six control subjects. These preparations were examined with a panel of monoclonal antibodies that have been shown to distinguish subpopulations of m...

The Corona Virus Disease (COVID-19) pandemic caused by Severe Acute Respiratory Syndrome 2 (SARS-CoV-2) requires a rapid solution and global collaborative efforts in order to define preventive treatment strategies. One of the major challenges this disease is high number patients needing advanced respiratory support due Distress (ARDS) as lung – although not exclusive target virus. molecular mec...


 Purpose: To investigate the action of miR-483-3p in pediatric pneumonia and identify potential biomarkers.
 Methods: Bronchoalveolar lavage was collected from 38 patients 25 healthy children. The expression determined using qRT-PCR. Alveolar macrophages children were cultured used for functional assays. Transwell assay conducted to evaluate macrophage cell migration. Cell viability ...