B1 and Alu are sequence-homologous interspersed elements of unknown function that have expanded in the genomes of mice and humans, respectively. A minority of B1 and Alu sequences are expressed as small cytoplasmic RNAs. These RNAs have conserved a secondary structure motif also present in signal recognition particle (SRP) RNA despite substantial sequence divergence, whereas random B1 and Alu s...

The verification of a bit-slice ALU has been accomplished using a mechanical theorem prover. This ALU has an n-bit design specification, which has been verified to implement its top-level specification. The ALU and top-level specifications were written in the Boyer-Moore logic. The verification was carried out with the aid of Boyer-Moore theorem prover in a hierarchical fashion.

A statistical analysis of a set of genomic human Alu elements is based on a published alignment and a recent classification of these sequences. After separation of the Alu sequences into families, the consensus sequences of these families are determined, using the correct weighting of the unidirectional decay of CG-dinucleotides. For, the tenfold greater mutation rate at CG's requires separate ...

Reconfigurable Computing has grown to become an important and large field of research. This paper describes the implementation of a reconfigurable ALU that combines 32-bit single precision floatingpoint adder and integer ALU (arithmetic logic unit) into a single unit on FPGA. Reconfigurable ALU can perform both integer operations and floatingpoint additions. Simply extending the operand width a...

A design methodology for implementing fast, easily testable arithmetic-logic units (ALU’s) is presented. Here, we describe a set of fast adder designs, which are testable with a test set that has either ( ) complexity (Lin-testable) or (1) complexity (C-testable), where is the input operand size of the ALU. The various levels of testability are achieved by exploiting some inherent properties of...

Highly repetitive DNA sequences account for more than 50% of the human genome. The L1 and Alu families harbor the most common mammalian long and short interspersed elements. An Alu element is a dimer of similar, but not identical, fragments of total size about 300 bp, and originates from the 7SL RNA gene. Each element contains a bipartite promoter for RNA polymerase III, a poly(A) tract located...

More than one million copies of the approximately 300-bp Alu element are interspersed throughout the human genome, with up to 75% of all known genes having Alu insertions within their introns and/or UTRs. Transcribed Alu sequences can alter splicing patterns by generating new exons, but other impacts of intragenic Alu elements on their host RNA are largely unexplored. Recently, repeat elements ...

CGGBP1 (CGG triplet repeat-binding protein 1) regulates cell proliferation, stress response, cytokinesis, telomeric integrity and transcription. It could affect these processes by modulating target gene expression under different conditions. Identification of CGGBP1-target genes and their regulation could reveal how a transcription regulator affects such diverse cellular processes. Here we desc...

Squirrel monkeys, Saimiri, are commonly found in zoological parks and used in biomedical research. S. boliviensis is the most common species for research; however, there is little information about genome evolution within this primate lineage. Here, we reconstruct the Alu element sequence amplification and evolution in the genus Saimiri at the time of divergence within the family Cebidae lineag...