Pseudorabies virus (PRV) glycoprotein E (gE) is a type I viral membrane protein that facilitates the anterograde spread of viral infection from the peripheral nervous system to the brain. In animal models, a gE-null mutant infection spreads inefficiently from presynaptic neurons to postsynaptic neurons (anterograde spread of infection). However, the retrograde spread of infection from post- to ...

UNLABELLED Many molecular and cell biological details of the alphaherpesvirus assembly and egress pathway remain unclear. Recently we developed a live-cell fluorescence microscopy assay of pseudorabies virus (PRV) exocytosis, based on total internal reflection fluorescence (TIRF) microscopy and a virus-encoded pH-sensitive fluorescent probe. Here, we use this assay to distinguish three classes ...

The spreading global sea turtle fibropapillomatosis (FP) epizootic is threatening some of Earth’s ancient reptiles, adding to the plethora threats faced by these keystone species. Understanding this neoplastic disease and its likely aetiological pathogen, chelonid alphaherpesvirus 5 (ChHV5), crucial understand how impacts populations species future trajectory incidence. We generated 20 ChHV5 ge...

Abstract Feline calicivirus (FCV), feline alphaherpesvirus 1 (FHV-1) and panleukopenia virus (FPLV) as well retroviral agents such leukaemia (FeLV) immunodeficiency (FIV) are important viral pathogens of cats. The aim this study was to detect characterise FHV-1, FPLV, FeLV, FIV foamy (FFV) in oropharyngeal, nasal conjunctival swabs from 93 cats that had been screened for FCV previously. We want...

Kedilerin solunum sisteminin en yaygın patojenlerinden biri olan Felid alphaherpesvirus 1 (FeHV-1) çoğunlukla ateş, mukopurulent nazal akıntı, konjunktivitis, iştahsızlık gibi semptomlarla seyretmekte ve özellikle yavru kedilerde alt sistemi enfeksiyonları sonrasında ölümlere neden olabilmektedir. dir. Enfeksiyonun bulaşması akut subklinik enfekte kedilere ait üst yolu sekret ekskretleri yoluyl...