Presence of a hydroxyl group at the C-3 position in guaianolides and at the C-5 position in alantolides has been established in biologically active compounds that act as plant-growth regulators. Sesquiterpene lactones like dehydrocostus lactone and isoalantolactone were subjected to allylic oxidations with selenium dioxide (SeO2) in combination with urea hydrogen peroxide (UHP) replacing the co...

Modification of dimethyl tartrate has been investigated through transesterification with aminoalcohols to provide reactive functionalities for the covalent bonding of chiral tartrate to polyhedral oligomeric silsesquioxanes. The transesterification of dimethyl tartrate has been widely studied using different catalytic systems and reaction conditions. Through the proper selection of both the cat...

The incorporation of uorine in pharmaceuticals and agrochemicals has become common practice due to the attractive properties that uorine can provide. Accordingly, uorination chemistry has been extensively explored in the last few decades to deliver uorinated compounds with various substitution patterns. Despite the great progress achieved for catalytic Csp3– F bond formation as well as aryl...

The synthesis of a small family of six electronically and sterically modified 1,3,4-trisubstituted 1,2,3-triazol-5-ylidene gold(I) chloride complexes is described. Additionally, the corresponding trans-[PdBr2(iPr2-bimy)(1,3,4-trisubstituted 1,2,3-triazol-5-ylidene)] complexes are also generated and used to examine the donor strength of the 1,3,4-trisubstituted 1,2,3-triazol-5-ylidene ligands. A...

Introduction of carbon side chain at C(3)-position of indole ring was accomplished by using Pd-catalyzed allylation and vinylation. The selective vinylation at C(3)-position of 4-bromoindole was applied to the synthesis of optically active 4-bromotryptophan derivatives, which was used as a starting material for the synthesis of several optically active ergot alkaloids, which were clavicipitic a...

Nitrogen-containing heterocycles are of great interest to organic chemists since they present in a wide array bioactive molecules. The use allylic alcohols carry out the allylation has been described as sustainable alternative for this type functionalization. Among plethora methodologies described, metals, solvents, or hazardous reagents is ubiquitous. protocol work provided solventless and met...

We have previously clarified that the strongly electron-withdrawing CF3 group nicely affected base-mediated proton shift of CF3-containing propargylic or allylic alcohols to afford corresponding α,β-unsaturated saturated ketones, respectively, which was applied this time Claisen rearrangement after O-allylation with a group, followed by isomerization allyl vinyl ethers via shift, enabling desir...