background: vaccinium arctostaphylos l. (caucasian whortleberry) fruit is used as an anti-hyperglycemic agent for treatment of diabetes mellitus. objective: the effects of whortleberry fruit and leaf extracts on the blood levels of fasting glucose, hba1c (glycosylated hemoglobin), insulin, creatinine and liver enzymes sgot and sgpt in alloxan-diabetic rats as well as ld50s of the extracts in ra...

Ethanol extract of pawpaw seed was evaluated for a possible application in the management diabetes. Alloxan used to induce diabetes rats, which were subsequently study antihyperglycaemic effect extract. Four (4) treatment groups and two (2) control 8 rats each created using complete randomized design. Triglyceride (TG), total cholesterol (TC), high density lipoprotein (HDL), low-density (LDL), ...

Purpose of the study. The assessment diabetes mellitus (DM) effect on levels sex hormones in tumor and peritumoral tissues BALB/c Nude mice with Lewis lung carcinoma (LLC). Materials methods . study included 42 male female aged 8–9 weeks weighing 21–22 g. Alloxan-induced DM was reproduced main group, then LLC transplanted. Levels estrone (E1), estradiol (E2), testosterone (T), progesterone (P4)...

The liver is an organ that serves several functions in the body, including glucose metabolism to provide energy other tissues. Hepatocytes are primary functional cells of liver, which also regulate release via transport protein-2. Hepatocyte injury could occur from toxic substances and diseases such as Diabetes Mellitus. Alloxan organic compound commonly used diabetes research a diabetogenic ag...

Objective: This study was carried out to investigate the combined effect of ethanolic leaf extracts C. papaya and N. laevis on histology testes alloxan-induced diabetic rats. Methodology: Forty male wistar rats weighing 150 -180 g were procured, acclimatized for two weeks, after which divided into eight groups five each, housed in cages. The designated as A - H. Group served control group, rece...

this study was conducted to evaluate the hypoglycemic, hypocholesterolemic and antioxidant properties of mentha spicata (labiateae) leaves aqueous extract (msla) in alloxan-induced diabetic rats. in this study, hyperglycemia was induced in male rats by intraperitoneal injection of alloxan monohydrate (150 mg/kg). the aqueous extract of m. spicata was orally administered at a dose of 300 mg/kg b...

Several recent studies have reported that alloxan-treated rats with long-term hyperglycemia can develop naturally occurring periodontal disease (PD). Our previous studies detected dental caries in the same model. Therefore, these two lesions of different etiologies are expected to occur concurrently. In this study, we evaluated the use of diabetic rats as a PD model by employing a selective COX...

BACKGROUND Patients suffering from diabetes show defective bacterial clearance. This study investigates the effects of elevated plasma glucose levels during diabetes on leukocyte recruitment and function in established models of inflammation. METHODOLOGY/PRINCIPAL FINDINGS Diabetes was induced in C57Bl/6 mice by intravenous alloxan (causing severe hyperglycemia), or by high fat diet (moderate...

1. Livers from normal and alloxan diabetic rats were perfused in vitro with a medium in which the concentration of free fatty acid was maintained at relatively constant levels by the infusion of a complex of oleic acid and bovine serum albumin. Concentrations of free fatty acid up to 3.5 mM in the cell-free perfusate were attained. 2. Throughout the range of concentration of free fatty acid whi...

In the present study, the hypoglycaemic potentials of ginger (Zingiber officinale) were studied in rats (four groups: control, ginger, diabetics and diabetics treated with ginger). Ginger extract was daily orally administered (400 mg/kg,) for 4 weeks to alloxan-induced diabetic rats (150 mg/kg). Fasting blood serum was analysed for blood glucose, insulin, creatinine, blood urea nitrogen, aspart...