Objective: Animal myocardial dysfunction induced by remote ischemia-reperfusion (IR) was shown to be partly accomplished via a direct effect of the pro-oxidant xanthine oxidase (XO). This direct remote effect was not tested in humans. We now assessed the performance of human auricles in the presence of solutions containing XO and/or allopurinol and compared them to those of rat myocardial strip...

OBJECTIVES Even though the use of combined drugs has been proved to be effective in other chronic infections, assessment of combined treatment of antiparasitic drugs in human Chagas' disease has not been performed. Herein, a pilot study was conducted to evaluate the tolerance and side effects of a sequential combined treatment of two antiparasitic drugs, allopurinol and benznidazole, in the chr...

BACKGROUND Stevens-Johnson syndrome (SJS) and Toxic Epidermal Necrolysis (TEN), caused by allopurinol therapy, are strongly associated with the human leukocyte antigen (HLA), HLA-B*5801. Identification of HLA-B*5801 genotype before prescribing allopurinol offers the possibility of avoiding allopurinol-induced SJS/TEN. As there is a paucity of evidence about economic value of such testing, this ...

More than three decades ago allopurinol was considered as a first line drug which regulate uric acid synthesis by inhibiting xanthine oxidase (XO) enzyme. . In addition to allopurinol, febuxostat is also used to reduce the synthesis of uric acid by inhibiting the XO enzyme and is approved by the European Medical Agency in 2008 and US FDA in 2009. . In contrast to allopurinol it acts on both red...

Background: Hyperuricemia contributes to kidney injury, characterized by tubular injury with epithelial–mesenchymal transition (EMT). Wnt5a/Ror2 signaling drives EMT in many kidney pathologies. This study sought to evaluate the involvement of Wnt5a/Ror2 in hyperuricemia-induced EMT in kidney tubular injury.Methods: A hyperuricemia model was performed in male Swiss background mice (3 months old,...

Allopurinol is now the first-line treatment for managing gout and its increasing usage has brought more patients at risk of developing allopurinol-induced hypersensitive reactions. Up to now, our attempts identify biomarkers hypersensitivity allopurinol are still finite. Besides, association between drug-induced reactions some mitochondrial DNA (mtDNA) alterations been proved but remains unclea...