BACKGROUND Fetal bilirubin is routinely measured at our center when taking a pretransfusion blood sample intrauterine transfusions in hemolytic disease of the fetus and newborn. However, clinical value fetal assessment not well known, information rarely used. We speculated that there could be role for this measurement predicting need neonatal exchange transfusion. OBJECTIVE This study aimed to ...

Abstract This study aims to determine the most frequent titers of anti-A and anti-B (both presumed immunoglobulin [Ig]M IgG) in Iranian group O blood donors compare these titer values with those found other studies. In addition, alloantibody production plasma levels four IgG subclasses were compared between high-titer non–high-titer groups. investigated 358 samples. Based on results, two groups...

Haemolytic disease of the foetus and newborn (HDFN) is caused by maternal red blood cells (RBC) alloimmunisation resulted from incompatibility of maternal and foetal RBCs. However, only a few HDFN attributed to anti-M were reported, varying from asymptomatic to severe anaemia with hydrops foetalis and even intrauterine death. A case of severe HDFN due to anti-M alloantibody from an alloimmunize...

We previously generated a monoclonal alloantibody, CR-50, by immunizing reeler mutant mice with homogenates of normal embryonic brains. This antibody recently was shown to recognize a Reelin protein, which is coded by the recently identified candidate gene for the reeler mutation. However, it is still unclear whether Reelin, especially the CR-50 epitope region, is indeed responsible for the ree...

Acute allograft rejection requires the activation of alloreactive CD4 T cells. Despite the capacity of B cells to act as potent APCs capable of activating CD4 T cells in vivo, their role in the progression of acute allograft rejection was unclear. To determine the contribution of B cell APC function in alloimmunity, we engineered mice with a targeted deficiency of MHC class II-mediated Ag prese...

Although HLA matching is beneficial in clinical transplantation, it is not feasible to select a completely HLA matched donor for every potential recipient because of the enormous polymorphism of the HLA system. As a consequence, the majority of the recipients will be transplanted with a mismatched donor organ or hematopoietic stem cell transplant. For this large group of patients it is importan...