The polymorphisms of the tumor suppressor gene p53 in exon 4 (p53 BstUI) and in intron 6 (p53 MspI) have been suggested to be associated with the genetically determined susceptibility in diverse types of human cancer. In our hospital-based case-control study, we examined the allele and genotype incidence of these polymorphisms as well as their haplotype combinations in 60 brain tumor patients (...

INTRODUCTION Arylamine N-acetyltransferase-2 (NAT-2) is a key human enzyme in drug detoxification and elimination. Mutations in NAT-2 affect the activity of anti-tuberculosis drugs and result in three different phenotypes: rapid (RA), intermediate (IA) and slow acetylators (SA). METHODOLOGY The allelic, genotypic and phenotypic frequencies of NAT-2 were studied in 185 patients from Buenos Air...

in view of the fundamental role of genetics in development of obesity, the present study aimed to investigate the single nucleotide polymorphism of some obesity-related genes among a subset of obese women living in tabriz, iran. for this purpose, 70 eligible obese women (aged 18-45 years) were genotyped for the uncoupling protein-1 (ucp-1) -3826a>g, ß3-adrenergic receptor (ß3adr) trp64arg, lept...

impulsive and convective frequencies are one of the most important subjects for evaluation of the seismic behavior of tanks. these two frequencies are defined by housner and used for obtaining rayleigh damping in time history analysis. aci 350 and nzsee standards have suggested some analytical solutions for finding convective and impulsive frequencies. these frequencies can also extract from mo...

The Fisher’s infinitesimal model is traditionally used in quantitative genetics and genomic selection, it attributes most genetic variance to additive variance. Recently, the dominance maximization was proposed prioritizes based on alternative parameterizations. In this model, effects at locus level are introduced into after maximized. study, new parameterizations of selection were evaluated co...

This study aimed to investigate the role of TGF-β1 gene in SARS-CoV-2 infection. A total 178 individuals diagnosed with Covid-19 participated and, they were divided two groups related outcome (discharge or death). Genotyping rs1800468 and rs1800469 polymorphisms was performed samples, using allelic discrimination technique expression analysis 93 samples by Real Time PCR. There no association be...

BACKGROUND The aim of our study was to investigate the allelic frequency of the G308A polymorphism in the TNF alpha gene and the influence of G308A this polymorphism on cardiovascular risk factors and adipokine levels in obese patients. DESIGN A population of 834 obesity patients was analyzed. A nutritional evaluation and a blood analysis were performed. The statistical analysis was performed...