The transmembrane distribution of phospholipids plays an important regulatory role in human erythrocytes. Membrane-bound translocase enzymes maintain an asymmetric phospholipid distribution across the membrane monolayers by promoting transmembrane diffusion or flip-flop. Mechanistic understanding of the flip-flop process is weak at the molecular level. Recently, we discovered that amide and sul...

Since the clock power consumption in today’s processors is considerably large, reducing the clock power consumption contributes to the reduction of the total power consumption in the processors. Recently, a gated flip-flop is proposed for reducing the clock power consumption of flip-flop circuits. The gated flip-flop employs a clock-gating circuit which cuts off an internal clock signal if the ...

Low power design is most required now a days due to scaling down the technology where minimizing the voltage level is the most effective way to minimize the power consumption. This paper presents a double pulse flip flop implemented using 0.18 μm technology. The proposed flip flop avoids unnecessary switching and stacking of transistors and thus consume less power as compared to conventional fl...

Flip-flop processes refer to a family of stochastic fluid which converge either standard Brownian motion (SBM) or Markov modulated (MMBM). In recent years, it has been shown that complex distributional aspects the univariate SBM and MMBM can be studied through limiting behavior flip-flop processes. Here, we construct two classes bivariate whose marginals strongly SBMs are dependent on each othe...

complies with the regulations of the University and meets the accepted standards with respect to originality and quality. In this thesis we propose a set of independent techniques in the overall concept of LC resonant clocking where each technique reduces power consumption and improve system performance. Low-power design is becoming a crucial design objective due to the growing demand on portab...

In the analysis of extra-vascular plasma concentration-time profiles, the disentanglement of influences from disposition and absorption rate influences is often challenging. This can be particularly true when absorption is considerably slower than disposition, that is, in a “flip-flop” system. The purpose of this communication is to define a pharmacokinetic flip-flop system (in a linear system)...

The flip and flop splice variants of AMPA receptors show strikingly different sensitivity to allosteric regulation by cyclothiazide; heteromers assembled from GluR-A and GluR-B also exhibit splice variant-dependent differences in efficacy for activation by glutamate and kainate. The sensitivity for attenuation of desensitization by cyclothiazide for homomeric GluR-A was solely dependent upon ex...

In our previous work we proposed a Multilayer Perceptron Neural Networks (MLP NN) consisting of fuzzy flipflops (F3) based on various operations. We showed that such kind of fuzzy-neural network had good learning properties. In this paper we propose an evolutionary approach for optimizing fuzzy flip-flop networks (FNN). Various popular fuzzy operation and three different fuzzy flip-flop types w...

The dynamics of the flip-flop motion of single buckled dimers of Si(100) was elucidated by locating the tip of a scanning tunneling microscope over a single flip-flopping dimer and measuring the tunneling current (time trace). Based on a statistical analysis of the time trace, we succeeded in estimating the activation energy and the energy splitting between the two stable configurations of buck...