To assess the impact of an estrogenic wastewater treatment plant (WWTP) effluent on fish reproduction, white suckers (Catostomus commersoni) were collected from immediately upstream and downstream (effluent site) of the city of Boulder, CO, WWTP outfall. Gonadal intersex, altered sex ratios, reduced gonad size, disrupted ovarian and testicular histopathology, and vitellogenin induction consiste...

A comprehensive evaluation of organic contamination was performed in sediments sampled in two reference and three impacted small streams where endocrine disruptive (ED) effects in fish have been evidenced. The approach combined quantitative chemical analyses of more than 50 ED chemicals (EDCs) and a battery of in vitro bioassays allowing the quantification of receptor-mediated activities, namel...

Alkylphenols are weak oestrogenic environmental contaminants and have been implicated in the disruption of endocrine function in wildlife. The influence of biotransformation, tissue distribution, and elimination on biological activity was investigated in juvenile rainbow trout following a single iv dose of [3H]4-nonylphenol. Distribution and elimination of [3H]4-nonylphenol residues in tissues ...

" When you can't run anymore, you crawl, and when you can't do that, you find someone to carry you "-Joss Whedon's Firefly ep.12-Till alla er som hjälpt till att bära i List of papers This thesis is based on the following papers, referred to in the text by their roman numerals, I-IV: I Lindqvist D., Dahlgren E., and Asplund L. (2017) Biosynthesis of hydroxylated polybrominated diphenyl ethers a...

BACKGROUND Estrogens are potent nongenomic phospho-activators of extracellular-signal-regulated kinases (ERKs). A major concern about the toxicity of xenoestrogens (XEs) is potential alteration of responses to physiologic estrogens when XEs are present simultaneously. OBJECTIVES We examined estrogen-induced ERK activation, comparing the abilities of structurally related XEs (alkylphenols and ...

Substantial research is currently focused on the toxicological effects of alkylphenol ethoxylates (APEs) and alkylphenols (APs) on aquatic animals. Considerable data are available on the concentrations of APEs and APs in river systems in the United States; however, few if any data are available on the tissue concentrations of fish living in these rivers. A reliable method for the analysis of no...

There is increasing concern about chemical pollutants that are able to mimic hormones, the so-called endocrine-disrupting compounds (EDCs), because of their structural similarity to endogenous hormones, their ability to interact with hormone transport proteins or because of their potential to disrupt hormone metabolic pathways. Thus, the effects of endogenous hormones can be mimicked or, in som...

An analytical method has been developed for the simultaneous extraction and determination of trace tertiary octylphenol (t-OP), technical nonylphenol isomers (NP), nonylphenol monoethoxylate isomers (NP1EO) and seven phthalates in sea water and the atmosphere using gas chromatography-mass spectrometry (GC-MS). Large volume samples were collected using a modified in-situ pump equipped with a PAD...

pharmaceuticals; alkylphenols used in the production of industrial detergents; and organochlorine pesticides including DDT, which is already banned in most developed countries [1, 2]. Although in adults the endocrine system has the ability to recover from fairly significant disturbances, in the foetus even minor changes in hormone levels may have lifelong effects. Because hormone receptor syste...

As a novel approach to characterize the phenolic pollutants of Lake Balaton (Central Europe, western Hungary), 26 endocrine disrupting phenols (chlorophenols, nitrophenols, alkylphenols, triclosan, bisphenol-A) were quantified in dissolved and suspended particulate matter (SPM) phases, alike. Sample collection was performed in the western and eastern basins, at 20 sites in April and October 201...