In a preliminary screen, Aaptos aaptos showed significant cytotoxic activity towards a panel of cell lines and was thus subjected to bioassay-guided isolation of the bioactive constituents. In addition to the known aaptamine, two new derivatives of the alkaloid were isolated from the bioactive chloroform fraction of the crude methanolic extract. Detailed analysis by NMR and mass spectroscopy en...

Scopolia lurida, a native herbal plant species in Tibet, is one of the most effective producers of tropane alkaloids. However, the tropane alkaloid biosynthesis in this plant species of interest has yet to be studied at the molecular, biochemical, and biotechnological level. Here, we report on the isolation and characterization of a putative short chain dehydrogenase (SDR) gene. Sequence analys...

Herbal medicines are respected for its medicinal values through generations. Areca catechu is commonly called as betel nut belonging to the family Arecaceae. Phytochemicals are the non-nutritive substances that protect the plant and human beings from diseases when consumed. In the present investigation, the aqueous extract of Areca catechu nut was analysed for the varieties of phytochemicals an...

The in vitro antimalarial activity against Plasmodium falciparum K1 of the four extracts from the stembark of Picrasma javanica Bl, that is, water, methanol, chloroform and hexane were studied using a modification of the [ 3 H]hypoxanthine incorporation method. It was found the chloroform extract showed in vitro antimalarial activity with IC50 of 20.0 g/ml. The extract was further isolated usi...

Objective: The present study was designed to investigate the analgesic effect of oral and i.p. administration of alcoholic Viscum album (V.A) fruit extract as a rich source of alkaloid substances. Materials and Methods: Experimented animals were divided into control and treatment groups. The treatment rats received different doses of the V.A fruit extract, which was prepared from alcoholic sma...

Antimicrobial agents play a crucial role in decreasing the impact of infectious diseases worldwide. Many medicinal plants have been identified as rich sources natural antimicrobial compounds that can be used an alternative to traditional treatments for bacterial infections. Indonesia, particularly Aceh region, has warm and humid climate supports diverse range properties. One example is lime (Ci...

HPLC-DAD-directed isolation and purification of the methanol extract of stems of Arcangelisia gusanlung H. S. Lo. led to the isolation of a new protoberberine alkaloid, gusanlung E (1), along with fourteen known derivatives 2-15, seven of which were obtained from the genus Arcangelisia for the first time. The structures and absolute stereochemistry of these compounds were elucidated on the basi...

Six new indole alkaloid sulfonic acids (1-6), together with two analogues (7 and 8) that were previously reported as synthetic products, were isolated from an aqueous extract of the Isatis indigotica root. Their structures including the absolute configurations were determined by spectroscopic data analysis, combined with enzyme hydrolysis and comparison of experimental circular dichroism and ca...

One new p-quinonoid aporphine alkaloid, obtusipetadione (1), and eleven known compounds (2-12) were isolated from the acetone extract of the twigs of Dasymaschalon obtusipetalum. Their structures were elucidated by spectroscopic methods. The cytotoxic and antimalarial activities of the isolated compounds were evaluated. Compound 1 showed significant in vitro antiplasmodial activity against the ...

Esenbeckia leiocarpa Engl. (Rutaceae), popularly known as guarantã, goiabeira, is a native tree from Brazil. Bioactivity-guided fractionation of the ethanol stems extract afforded the isolation of six alkaloids: leiokinine A, leptomerine, kokusaginine, skimmianine, maculine and flindersiamine. All isolated compounds were tested for acetyl cholinesterase inhibition, in vitro and displayed antich...