Abnormal spindle (Asp) is a 220-kD microtubule-associated protein from Drosophila that has been suggested to be involved in microtubule nucleation from the centrosome. Here, we show that Asp is enriched at the poles of meiotic and mitotic spindles and localizes to the minus ends of central spindle microtubules. Localization to these structures is independent of a functional centrosome. Moreover...

BACKGROUND It has long been debated whether Asperger's Syndrome (ASP) should be considered part of the Autism Spectrum Disorders (ASD) or whether it constitutes a unique entity. The Diagnostic and Statistical Manual, fourth edition (DSM-IV) differentiated ASP from high functioning autism. However, the new DSM-5 umbrellas ASP within ASD, thus eliminating the ASP diagnosis. To date, no clear biom...

Acinetobacter baumannii is an opportunistic pathogen that is frequently involved in outbreaks of infection, occurring mostly in intensive care units. The increasing incidence of carbapenem resistance in A. baumannii worldwide is a concern since it limits drastically the range of therapeutic alternatives. The most important mechanism of carbapenem resistance is the enzymatic hydrolysis mediated ...

In the title compound {systematic name: 5-tert-butyl-3-[2,4-di-chloro-5-(prop-2-yn-yloxy)phen-yl]-1,3,4-oxa-diazol-2(3H)-one}, C15H14Cl2N2O3, which is an oxa-diazo-lone herbicide, the dihedral angle between the planes of the oxa-diazo-lone and benzene rings is 65.84 (6)°. In the crystal, weak inter-molecular Cl⋯Cl [3.3600 (7) Å] short contacts link adjacent mol-ecules, forming chains along the ...

Since the first anthracycline was discovered, many other related compounds have been studied in order to overcome its defects and improve efficacy. In the present paper, we investigated the anticancer effects of a new anthracycline, aspergiolide A (ASP-A), from a marine-derived fungus in vitro and in vivo, and we evaluated the absorption, distribution, metabolism, and toxicity drug properties i...

We translate the concept of backdoor trees from SAT to propositional Answer Set Programming (ASP). By means of backdoor trees we can reduce a reasoning task for a general ASP instance to reasoning tasks on several tractable ASP instances. We demonstrate that the number of tractable ASP instances can be drastically reduced in comparison to a related approach based on strong backdoors.

Acylation stimulating protein (ASP), a novel adipocyte-derived autocrine protein, stimulates triglyceride synthesis and glucose transport in vitro in human and murine adipocytes. In vitro, chylomicrons increase ASP and precursor complement C3 production in adipocytes. Furthermore, in vivo, ASP production from human adipose tissue correlates positively with triglyceride clearance postprandially....

− With the advance of Internet technology and network bandwidth, Application Service Provider (ASP) mode of computing is becoming a very attractive target of the next wave of Internet revolution. However, the ASP model and its implementation technologies have not been thoroughly investigated. In this paper we highlight the essence, benefits, and importance of the ASP model as the first form of ...

Facile synthetic access to the isolable, thermally robust AsP(3) molecule has allowed for a thorough study of its physical properties and reaction chemistry with a variety of transition-metal and organic fragments. The electronic properties of AsP(3) in comparison with P(4) are revealed by DFT and atoms in molecules (AIM) approaches and are discussed in relation to the observed electrochemical ...

Study Design Retrospective cohort study. Objective To identify the incidence of adjacent segment pathology (ASP) after thoracolumbar fusion of three or more levels, the risk factors for the development of ASP, and the need for further surgical intervention in this particular patient population. Methods A retrospective analysis of a prospective surgical database identified 217 patients receiving...