Fish scale biopolymer blended with nanocellulose crystals is used for production of microneedles applying mechanical press microfabrication and the effect of nanocellulose on microfabrication, water absorption, moisture stability and mechanical properties of the microneedles is reported. The results show that microneedles produced from the nanocellulose loaded fish scale biopolymer requires hig...

BACKGROUND AND PURPOSE Coil embolization is safe and effective but may be followed by aneurysm recurrence. Our purpose was to explore the use of alginate as a new embolic agent that could deliver growth factors and improve results of endovascular treatment of aneurysms. METHODS We first assessed the potential of alginate as a vector for growth factor delivery by using in vitro binding and elu...

alginate hydrogel and honey have a notably effect on wound healing process, therefore assessment of combined impact of those are essential. in this study, the effect of homey-based alginate hydrogel, alginate hydrogel and commercial alginate dressings in recovery of wound in a mouse model was studied. in this study, 20 wistar rats were divided into four groups of five. one wound with dimension ...

in recent years, encapsulation of drugs and antigens in hydrogels, specifically in calcium alginate particles, is an interesting and practical technique that was developed widespread. it is well known that alginate solution, under proper conditions, can form suitable nanoparticles as a promising carrier system, for vaccine delivery. the aim of this study was to synthesis alginate nanoparticles ...

Despite the success of alginate scaffolds and mesenchymal stem cells (MSCs) therapy in cardiac failure treatment, the impact of the physicochemical environment provided by alginate matrices on cell behavior has never been investigated. The purpose of this work was double: to determine the alginate composition influence on (1) encapsulated rat MSC viability, paracrine activity, and phenotype in...

18 Alginate lyases are enzymes that degrade alginate through β-elimination of the glycosidic bond 19 into smaller oligomers. We investigated the alginate lyases from Vibrio splendidus 12B01, a 20 marine bacterioplankton species that can grow on alginate as its sole carbon source. We 21 identified, purified, and characterized four polysaccharide lyase family 7 alginates lyases – 22 AlyA, AlyB, A...

Alginate, a non-toxic polysaccharide isolated from brown algae, is a widely used 3-dimensional (3D) porous scaffold for the granulosa cell and follicle encapsulation. However, impurities in commercial alginate can lead to alginate biocompatibility reduction. The aim of this study was to evaluate in vitro behavior of the granulosa cells seeded on the purified alginate in varying concent...

INTRODUCTION Alterations in the vocal folds that involve volume reduction and glottal closure failure result in exaggerated air escape during speech. For such situations, the use of implants or grafts of different materials has been proposed. OBJECTIVE To define the effect of sugarcane biopolymer gel when implanted in the vocal folds of rabbits. METHODS This was an experimental study. The v...

The aim of the research work was to isolate biopolymer and to evaluate its emulsifying ability by formulating o/w type of emulsion. The biopolymer was isolated from the fruit pulp of Prunus insititia by treating with water. The aqueous extract was treated with an optimized ratio of dimethyl ketone and kept in refrigeration for 6 hours. The biopolymer was collected by centrifugation, dried and s...

PURPOSE To evaluate the benefit of using carriers such as the biopolymer gel (hidrogel of polysaccharide of sugarcane molasses) associated with the bone morphogenetic proteins (BMP's) in the repair of critical bone defects in calvaria of Wistar rats. METHODS Forty-two rats were submitted to a surgical calvaria bone defects. These animals were divided into two experimental groups, positive con...