BACKGROUND Hepatic stellate cell (HSC) has been suggested to play a role in fibrogenesis in alcoholic liver disease. We evaluate the correlation with fibrogenesis and ultrastructure of hepatic stellate cells in alcoholic fatty liver. METHODS We studied 6 patients with alcoholic fatty liver and 5 non-alcoholic fatty liver. The numbers of fat droplets in hepatic stellate cell was determined by ...

Liver cirrhosis, a late stage of hepatic fibrosis, is an increasing cause of morbidity and mortality worldwide. Hepatic fibrosis is mainly caused by alcoholic or non-alcoholic steatohepatitis, chronic viral hepatitis, or autoimmune and biliary diseases. Myofibroblasts, which are absent from the normal liver, are differentiated from heterogeneous cell populations in response to a liver injury of...

Adiponectin, which plays a pivotal role in metabolic liver diseases, is reduced in concentration in patients with NASH (non-alcoholic steatohepatitis). The aim of the present study was to determine adiponectin concentrations in patients with different forms and stages of chronic liver diseases. Serum adiponectin concentrations were measured in 232 fasting patients with chronic liver disease: 64...

BACKGROUND Alcoholic liver disease has emerged as a leading indication for hepatic transplantation, although it is a controversial use of resources. We aimed to examine all aspects of liver transplantation associated with alcohol abuse. METHODS Retrospective cohort analysis of 123 alcoholic patients with a median of 7 years follow-up at one center. RESULTS In addition to alcohol, 43 (35%) p...

nonalcoholic fatty liver disease (nafld) is one of the aspects of metabolic syndrome (mets). due to the increase of mets in iran, this study was conducted to determine the prevalence of nafld, its potential predictors and their sex distribution in north of iran, amol.in 2008 this population based cross-sectional study included 5023 adult individuals who were randomly selected from amol healthca...

background a strong association between obesity and non-alcoholic fatty liver disease (nafld) has been reported. objectives this study was conducted to evaluate if new obesity indices, including a body shape index (absi) and body roundness index (bri), have stronger associations with nafld than waist-to-hip ratio (whr) and waist-to-height ratio (whtr). methods in this cross-sectional study, we ...

nonalcoholic fatty liver disease (nafld) is an obesity-associated disease and dysregulation of adipokines has an important role in its development. omentin-1 (itln1 protein) and resistin are two adipokine secreted from adipose tissue. single nucleotide polymorphisms in the adipokine genes may affect expression and activity of the adipokine, and thus play a contributory role in nafld pathogenesi...