Rapid clinical deteriorations have been reported after abrupt discontinuation of clozapine. A 42-year-old psychiatric patient presented with ingestion of hand-disinfectant solutions causing transient impairment of his conscious level. His clozapine therapy was discontinued for a short period of time and he developed delirium with normal results of investigations for underlying organic causes. H...

Detection of auditory signals by frog inferior collicular neurons in the presence of spatially separated noise. J. Neurophysiol. 80: 2848-2859, 1998. Psychophysical studies have shown that the ability to detect auditory signals embedded in noise improves when signal and noise sources are widely separated in space; this allows humans to analyze complex auditory scenes, as in the cocktail-part ef...

Using a method recently developed at our laboratory, we determined the initial rate of Pseudomonas aeruginosa replication in the lung under different experimental conditions. Mice were exposed to aerosols containing mixtures of a temperature-sensitive (ts) mutant of P. aeruginosa and its parental wild type (wt). The changes in the ratio of ts:wt were determined by quantitatively culturing homog...

BACKGROUND The Internet enables businesses to advertise their pharmaceutical products and services without medical supervision. The Internet also allows for the unsupervised purchase of medications that may have neurologic consequences. OBJECTIVE To describe acute withdrawal delirium following the abrupt discontinuation of Fioricet. PATIENT The patient was a 37-year-old woman with a history...

Objective(s): Ethanol withdrawal following chronic use, is an important challenge clinically. In this study, the effect of clavulanic acid was evaluated on the symptoms of ethanol withdrawal in rats. Materials and Methods: Alcohol dependence was induced by the gavage of ethanol (10% v/v, 2 g/kg), twice daily for 10 days. Clavulanic acid ...

Introduction Patients in psychiatric department, especially the intensive care unit, often develop delirium syndrome, which leads to a high risk of morbidity and mortality. The etiology is multifactorial. most common causes are alcoholism dementia. Pharmacological treatment delirious syndrome important part treatment, includes various psychopharmaceuticals that effective both improving cognitiv...

Delirium is highly prevalent, occurring in 20% of acute hospital inpatients and up to 62% of surgical patients. It is a significant predictor of poor outcomes including mortality and institutionalisation, however it is often viewed as simply a marker of underlying illness and is frequently overlooked in older adults. Although delirium is commonly comorbid with dementia, it represents a more urg...

Abstract Introduction Alcohol has depressant effects on the central nervous system through its effect inhibitory GABAA receptors. In chronic excessive alcohol use, receptors undergo neuroadaptation, and so, in abrupt withdrawal upon admission into hospital, remains a hyperactive state, resulting syndrome (AWS), can progress to seizures delirium tremens if not managed appropriately. National gui...