Albinism, partial albinism, and vitiligo are three clinically distinct conditions having in common a deficiency of melanin pigment. As such they present the physician with the same basic problems-cosmetically disfiguring lesions and extreme sensitivity to sunlight of the involved areas. None of the diseases is itself an immediate threat to life, but the social disabilities, especially among dar...

PURPOSE To investigate the retinal toxicity by electroretinography (ERG), clinical examination and histology after intravitreal injection of biological stains in two concentrations: Trisodium (0.50 g/L and 1.00 g/L), Orangell (0.25 g/L and 1.00 g/L) and Methyl Violet (0.50 g/L and 1.00 g/L). METHODS Eighteen New-Zealand albinos rabbits were assigned in six groups (n = 3 in each group). The an...

PURPOSE To investigate the effect of retrograde tracing or axotomy on melanopsin mRNA expression and immunodetection in albino and pigmented rat retinas. METHODS Groups were (1) intact-naïve retinas; (2) optic nerve crush (ONC) analyzed at 7 days (7d) or 2 months (2m); (3) Fluorogold (FG) tracing from the superior colliculi (SCi) analyzed at 7d or 2m; (4) tracing from the intact optic nerve (...

Thirty-four independent nonviable c-locus mutations (types cal, albino lethal and cas, albino subvital), derived from radiation experiments, were tested for involvement of nearby markers tp, Mod-2, sh-1, and Hbb: 10, 22, and 2 involved, respectively, none of these markers, Mod-2 alone, and Mod-2 plus sh-1. When classified on this basis, as well as according to developmental stage at which homoz...

PURPOSE BALB/cByJ (C) albino mice have significantly more retinal degeneration as they age than C57BL/6J-c(2J) (B6) albinos. To discover the genetic loci that influence age-related retinal degeneration (ARD), a quantitative genetics study was performed with 8-month-old progeny from an intercross between these two strains. METHODS The thickness of the outer nuclear layer of the retina was used...

K eloid scars—fibrous overgrowths that occur in sites of previous skin injury—are composed of excess collagen and often extend beyond the borders of the original wound (Figure 1). Keloids often develop soon after injury but can also occur up to several years following the initial traumatic insult. Common causes include surgical procedures, piercings, vaccinations, lacerations, and burn injuries...

HEDIAK (1952) observed anomalous granulations in peripheral blood and bone marrow leukocytes of a four-year-old girl. Several investigators have since reported similar granules in leukocytes of both male and female patients from different parts of the world. While there have been some differences reported in the various cases, the composite picture of the syndrome as described by several invest...

Since the beginning of 1940 a strain of albino mice has been bred in the Department of Hygiene and Bacteriology mainly for the purpose of studying mouse poliomyelitis. The descent of this strain is not definitely known, but it is probably a mixed breed of Swiss mice obtained from Denmark. It has later been crossbred with ordinary grey-coated wild mice (Mus musculus), the albinos of the F2 gener...

While investigations were in progress elsewhere in Venezuela on the modifications of the reactions to tuberculin and lepromin after BeG vaccination in groups of humans in leprosy-endemic foci (2). parallel experiments were made with hamsters and guinea-pigs at the Cabo Blanco Leprosarium. The results are reported here. The problem of lepromin sensitization in animals has attracted the attention...