During the acute-phase reaction, SAA (serum amyloid A) replaces apoA-I (apolipoprotein A-I) as the major HDL (high-density lipoprotein)-associated apolipoprotein. A remarkable portion of SAA exists in a lipid-free/lipid-poor form and promotes ABCA1 (ATP-binding cassette transporter A1)-dependent cellular cholesterol efflux. In contrast with lipid-free apoA-I and apoE, lipid-free SAA was recentl...

Introduction: splenic artery aneurysm (sAA) is an uncommon and potentially life-threatening clinical entity that carries a risk of rupture and peritoneal hemorrhage. case report: this is a case of a splenic artery aneurysm incidentally diagnosed in a 55-year-old male. Diagnosis was confirmed by abdominal computed tomography (ct) scan and the patient was managed by surgical approach because of t...

Splenic Artery Aneurysm (SAA) remains rare pathology. Although rare, the SAA is the most common visceral artery aneurysm with 4:1 female-to-male predominance, commonly located in the distal third of the splenic artery (75% of cases). It remains asymptomatic in over 95% of patients. Patients with this type of aneurysm often present without symptoms and the SAAs are often found during investigati...

Serum amyloid A proteins (SAA), presumed precursors of the tissue amyloid A proteins (AA) characteristic of secondary amyloidosis, have been isolated from the plasma high-density lipoproteins (HDL) of normals after etiocholanolone-induced inflammation and from patients with Wegener's granulomatosis, systemic lupus erythematosis, juvenile rheumatoid arthritis, Waldenström's macroglobulinemia, an...

BACKGROUND Serum amyloid-alpha (SAA) is a sensitive marker of an acute inflammatory state. Like high-sensitivity C-reactive protein (hs-CRP), SAA has been linked to atherosclerosis. However, prior studies have yielded inconsistent results, and the independent predictive value of SAA for coronary artery disease (CAD) severity and cardiovascular events remains unclear. METHODS AND RESULTS A tot...

Salivary alpha-Amylase (sAA) is a starch digesting enzyme. In addition to its function in the context of nutrition, sAA has also turned out to be useful for monitoring sympathetic nervous system activity. Recent studies on humans have found a relationship between intra-individual changes in sAA activity and physical and psychological stress. In studies on primates and other vertebrates, non-inv...

Serum amyloid A (SAA) is an apolipoprotein involved in poorly understood roles in inflammation. Upon trauma, hepatic expression of SAA rises 1000 times the basal levels. In the case of inflammatory diseases like rheumatoid arthritis, there is a risk for deposition of SAA fibrils in various organs leading to Amyloid A (AA) amyloidosis. Although the amyloid deposits in AA amyloidosis accumulate w...

Bella, Deborah L., Christine Hahn, and Martha H. Stipanuk. Effects of nonsulfur and sulfur amino acids on the regulation of hepatic enzymes of cysteine metabolism. Am. J. Physiol. 277 (Endocrinol. Metab. 40): E144–E153, 1999.—To determine the role of nonsulfur vs. sulfur amino acids in regulation of cysteine metabolism, rats were fed a basal diet or diets supplemented with a mixture of nonsulfu...

OBJECTIVE To compare serum amyloid A (SAA) concentration, plasma fibrinogen concentration, total WBC count, and serum albumin-to-globulin concentration ratio (A:G ratio) in clinically normal (CN) and clinically abnormal (CA) horses. DESIGN Prospective cohort study. ANIMALS 111 CN horses and 101 CA horses hospitalized at a specialty clinical practice. PROCEDURES Shortly after admission, a ...