INTRODUCTION Both admission hyperglycemia (AH) and diabetes mellitus adversely affect the prognosis in acute coronary syndromes. We prospectively assessed the predictive role of AH in patients with acute ST-segment elevation myocardial infarction (STEMI). METHODS Three hundred-one consecutive patients hospitalized for STEMI were enrolled. Patients were stratified into four groups based on the...

BACKGROUND Platelet-activating factor (PAF) is a highly potent phospholipid mediator responsible for the life-threatening manifestations of anaphylaxis. PAF acetylhydrolase (PAF-AH) inactivates PAF and protects against severe anaphylaxis whereas deficiency of PAF-AH predisposes to severe or fatal anaphylaxis. Determinants of PAF-AH activity have not been studied in patients with peanut allergy....

Aromatic hydrocarbon (AH) effects are mediated by binding of the AH receptor and its heterodimeric partner aromatic hydrocarbon nuclear translocator to specific response elements on DNA (AHREs). CYP1A2 expression is induced by AHs, yet AHREs have been identified in CYP1A2 genes of only two species and their functional role assessed only in the human gene. There have been few analyses of CYP1A2 ...

Sažetak Arterijska hipertenzija (AH) jedan je od najvažnijih sprečivih (preventabilnih) uzroka prijevremenog umiranja i jedan od najvećih javnozdrastvenih problema današnjice u svijetu. Prevalencija AH je veća nego ranije i kreće se oko 40% u odraslim populacijama europskih zemalja, dok je u Sjedinjenim Američkim Državama značajno niža. Prema rezultatima studije “Epidemiologija arterijske hiper...

BACKGROUND It is difficult to determine whether to treat a given girl who has idiopathic central precocious puberty (CPP) with gonadotropin-releasing hormone analog (GnRHa) in terms of adult height (AH). The objective was to provide an easy tool for predicting AH and age at first menstruation at initial evaluation to help guide the decision regarding whether to treat. METHODS Data analysis us...

INTRODUCTION Models of atmospheric processes simulate only certain spatial and temporal scales. The observations used to test the performance of these models are individual realizations (which can be envisioned as coming from ideal ensembles), and are affected by variations unaccounted for within the simulation model. Given this, it makes sense to ask the models to replicate variations having c...

As the oven temperature is raised at a reproducible rate, analytes are eluted and the areas under the chromatogram are recorded. Boiling points are assigned to the time axis from a calibration curve, known as the boiling-point distribution curve, based on a known mixture of normal paraffin hydrocarbons over a fixed range. These paraffin hydrocarbons serve as markers, which identify the time tha...

Normal rat bile contains secretory platelet-activating factor acetylhydrolase (PAF-AH), the enzyme capable of hydrolyzing the inflammatory mediator platelet-activating factor (PAF), and phospholipids containing oxidized truncated fatty acids. Because lecithin:cholesterol acyltransferase (LCAT) possesses intrinsic PAF-AH-like activity, it also may represent a potential anti-inflammatory enzyme. ...

BACKGROUND Platelet-activating factor acetylhydrolase (PAF-AH), also denoted as lipoprotein-associated phospholipase A2, is a lipoprotein-bound enzyme that is possibly involved in inflammation and atherosclerosis. This study investigates the relationship of PAF-AH activity to angiographic coronary artery disease (CAD), the use of cardiovascular drugs, and other established risk factors. METHO...