Chlamydia lung infection caused by trachomatis is a serious particularly in infants but there are few studies about infection. Chlamydial genital and infections mice frequently done with muridarum. The purpose of our study was to explore the effect stress chlamydia male mice. We hypothesize that changes level cytokine production monocytes during As result from these include counting live cells,...

Objective Coasting can reduce the ovarian hyperstimulation syndrome (OHSS) risk in ovulation induction cycles before intracytoplasmic sperm injection (ICSI). This study aimed to investigate the effect of gonadotropin-releasing hormone (GnRH) agonist and GnRH antagonist protocols to controlled ovarian hyperstimulation (COH) cycles with coasting on the parameters of ICSI cycles and the outcome. M...

Adiponectin, a hormone secreted from adipocytes, is closely associated with psoriasis and suppresses psoriasiform inflammation. Recently, small-sized transdermally deliverable 5-mer peptide (GLYYF; P5) was discovered as potential adiponectin receptor 1 agonist. This study aims at confirming the reduction of protein level in human skin investigating whether functional replenishment by topical P5...

It is well established that serotonin (5-HT; 5-hydroxytryptamine) plays a role in mammalian regulation of the hypothalamic-pituitary-adrenal (HPA) axis via the 5-HT receptor subtype 1A (5-HT(1A)). To date, there has not been a comprehensive investigation of the molecular, pharmacological and physiological aspects of the 5-HT(1A) receptor and its role in the activation of the hypothalamic-pituit...

The concept of functional selectivity has now thoroughly supplanted the previously entrenched notion of intrinsic efficacy by explaining how agonists and antagonists exhibit a range of efficacies for distinct receptor-mediated responses. It is noteworthy that functional selectivity accommodates significant changes in efficacy resulting from differential expression of G protein-coupled receptor ...

The serotonin(2C) (5-HT(2C)) receptor couples to multiple effector mechanisms, including phospholipase A(2)-mediated arachidonic acid (AA) release and phospholipase C-mediated production of inositol phosphates (IP). Agonist relative efficacy differs depending upon which response (AA release or IP accumulation) is measured. In this study, we investigated the characteristics and agonist dependenc...

The 5-hydroxytryptamine 2C (5-HT(2C)) receptor subtype has received considerable attention as a target for drug discovery, having been implicated in a wide variety of disorders. Here, we describe the in vitro pharmacological profile of the novel 5-HT(2C) receptor-selective agonist vabicaserin [(-)-4,5,6,7,9,9a,10,11,12,12a-decahydrocyclopenta[c] [1,4]diazepino[6,7,1-ij]quinoline hydrochloride] ...

The calcium-sensing receptor (CaSR) is expressed in various tissues, including the gastrointestinal tract. To investigate the role of gut CaSR on glycemic control, we examined whether single oral administration of CaSR agonist peptides affected the glycemic response in rats. Glucose tolerance tests were performed under oral or duodenal administration of various CaSR agonist peptides (γGlu-Cys, ...

Serotonin 1A receptor (5-HT(1A)R) agonists have emerged as valuable supplements to l-DOPA therapy, demonstrating that they can decrease side effects and enhance motor function in animal models of Parkinson's disease (PD) and human PD patients. The precise mechanism by which these receptors act remains unknown and there is limited information on how 5-HT(1A)R stimulation impacts striatal dopamin...

CRTH2: Chemoattractant Receptor-Homologous Molecule Expressed On Th2 Cells; COPD: Chronic Obstructive Pulmonary Disease; WHO: World Health Organization; SIT: Allergen-Specific Immunotherapy; ICS: Inhaled Corticosteroids; LABA: LongActing-Β-Agonist; SABA: Short-Acting-Β-Agonist; MDI: Metered Dose Inhaler; 5-LO: 5-Lipoxygenase; FLAP: 5-LipoxygenaseActivating Protein; 5-Oxo-ETE: 5-Oxo-6,8,11,14-Ei...