A middle-aged man with multiple comorbidities including uncontrolled diabetes mellitus presented shortness of breath and lethargy for six days. He was treated COVID-19 pneumonia, requiring high cumulative steroid therapy. After 15 days treatment, he developed right orbital apex syndrome central retinal artery occlusion secondary to invasive mucormycosis. The infection progressed rapidly despite...

Peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS) is a heterogeneous category of nodal and extranodal mature T-cell lymphomas. PTCL-NOS is a highly aggressive lymphoma, and its prognosis is poorer than those of aggressive B-cell lymphoma such as diffuse large B-cell lymphoma(DLBCL). Current standard chemotherapies for aggressive B-cell lymphoma, such as CHOP, are the commonly used ...

Purpose: Malignant pleural mesothelioma (MPM) is an aggressive and therapy-resistant neoplasm arising from the pleural mesothelial cells, without established indicators to predict responsiveness to

Prognosis for metastatic melanoma has improved significantly with the use of immune checkpoint inhibitors. Given improvements in survival, aggressive surgical treatment may be considered in patients with life-threatening complications from their disease that would not otherwise be considered in advanced disease. Patients with preexisting autoimmune diseases or prior immune-related adverse event...

Background and Objective: Clinical behavior of basal cell carcinoma (BCC) is known to be different according to histological growth pattern and basosquamous cell carcinomas (BSC) are known with their aggressive behavior and metastatic capacity. In this study, we evaluated bcl-2 and cyclin D1 expressions in BCC and BSC cases comparatively, to explore their predictive value on the aggres...

An argument is presented here for postherpetic neuralgia as an intractable end-stage disorder for many patients. The exciting possibility of prevention of this disorder by early, aggressive treatment exists; however, the extent to which therapy can be effective is unknown. Early, aggressive treatment of the pain of herpes zoster is, nevertheless, urged, and the options for treatment are discuss...

B-precursor acute lymphoblastic leukaemia (BPL) is the most common form of cancer in children and adolescents. Our recent studies have demonstrated that CD22ΔE12 is a characteristic genetic defect of therapy-refractory clones in paediatric BPL and implicated the CD22ΔE12 genetic defect in the aggressive biology of relapsed or therapy-refractory paediatric BPL. The purpose of the present study i...

Locoregional recurrence (LRR) of breast cancer can occur after multidisciplinary treatment of a primary breast cancer. With modern multidisciplinary breast cancer treatment, the incidence of isolated LRR is decreasing. Improvements in systemic therapy are driving the decrease in LRR. LRR does still occur, however. LRR reflects biology of the cancer, as does systemic recurrence. LRR of breast ca...

Merkel cell carcinoma is a rare, rapidly progressive, aggressive skin tumor with frequent metastasis and high mortality. The disease multifactorial pathology resulting from the interaction of endogenous exogenous risk factors. Timely detection important in management prognosis patient, because often associated other neoplastic processes not only but also organs. This article presents clinical c...